Invitrogen

TLX Polyclonal Antibody

查看其他14个TLX抗体
说明书
实验方案
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说明书
实验方案
技术支持

产品信息

PA5-103055

应用
建议稀释比
已发表文章

免疫印迹 (WB)

1:1,000-1:3,000
-

免疫组化（石蜡） (IHC (P))

1:50-1:200
-
产品规格

种属反应

Human, Mouse, Rat

宿主/亚型

Rabbit / IgG

分类

Polyclonal

类型

Antibody

抗原

A synthesized peptide derived from human NR2E1(Accession Q9Y466), corresponding to amino acid residues G141-R191.
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偶联物

Unconjugated Unconjugated Unconjugated

形式

Liquid

浓度

1 mg/mL

纯化类型

Affinity chromatography

保存液

PBS, pH 7.4, with 50% glycerol

内含物

0.02% sodium azide

保存条件

-20°C

运输条件

Wet ice

RRID

AB_2852425

产品详细信息

Antibody detects endogenous levels of total NR2E1.

靶标信息

Nuclear receptor TLX, a NR2 hepatocyte NF4-like receptor, has been shown to affect anterior brain differentiation, retinal development, and vision. It has been suggested that TLX targets genes for RAR beta2 and Pax2 during retinal development. Homozygous TLX mutant mice are viable at birth but exhibit reduced forebrain development and are more aggressive than wild-type mice. Mice with deleted TLX locus exhibit cerebral hypoplasia, blindness, and extreme aggression (fierce (frc) phenotype). TLX expression has been documented in mouse brain and eye. ESTs have been isolated from normal human brain libraries.

仅用于科研。不用于诊断过程。未经明确授权不得转售。

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引用该产品

生物信息学

蛋白别名: HTll; Nuclear receptor subfamily 2 group E member 1; nuclear receptor subfamily 2, group E, member 1; Nuclear receptor TLX; Protein tailless homolog; tailes-related receptor; tailless homolog; Tll

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基因别名: fierce; frc; Mtl1; Mtll; NR2E1; tailless; TLL; TLX; XTLL

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UniProt ID: (Human) Q9Y466, (Mouse) Q64104

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Entrez Gene ID: (Human) 7101, (Rat) 684085, (Mouse) 21907

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功能
transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding steroid hormone receptor activity zinc ion binding histone deacetylase binding sequence-specific DNA binding DNA binding enzyme binding transcription factor activity, sequence-specific DNA binding protein binding metal ion binding C4 zinc finger nuclear receptor
参与通路
negative regulation of transcription from RNA polymerase II promoter behavioral fear response aggressive behavior transcription initiation from RNA polymerase II promoter nervous system development visual perception dentate gyrus development amygdala development olfactory bulb development layer formation in cerebral cortex forebrain generation of neurons cerebral cortex neuron differentiation anterior commissure morphogenesis extracellular matrix organization somatic stem cell population maintenance social behavior negative regulation of apoptotic process steroid hormone mediated signaling pathway cell fate commitment negative regulation of neuron differentiation positive regulation of angiogenesis positive regulation of cell cycle positive regulation of transcription from RNA polymerase II promoter negative regulation of astrocyte differentiation regulation of dendrite morphogenesis retina development in camera-type eye regulation of timing of neuron differentiation long-term synaptic potentiation regulation of cell migration involved in sprouting angiogenesis negative regulation of neural precursor cell proliferation positive regulation of neural precursor cell proliferation positive regulation of stem cell proliferation transcription, DNA-templated transcription from RNA polymerase II promoter brain development positive regulation of cell proliferation glial cell migration cerebral cortex development camera-type eye development regulation of cellular component organization regulation of transcription, DNA-templated multicellular organism development
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