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产品信息
MA5-24949
产品规格
种属反应
Human
已发表种属
Human
宿主/亚型
Mouse
/ IgG1
分类
Monoclonal
类型
Antibody
克隆号
OTI10G3
抗原
Full length human recombinant protein of TMEM100 produced in HEK293T cell
偶联物
形式
Liquid
浓度
1 mg/mL
纯化类型
Affinity Chromatography
保存液
PBS, pH 7.3, with 1% BSA, 50% glycerol
内含物
0.02% sodium azide
保存条件
-20° C, Avoid Freeze/Thaw Cycles
运输条件
Ambient (domestic); Wet ice (international)
RRID
AB_2725530
靶标信息
Plays a role during embryonic arterial endothelium differentiation and vascular morphogenesis through the ACVRL1 receptor-dependent signaling pathway upon stimulation by bone morphogenetic proteins, such as GDF2/BMP9 and BMP10. Involved in the regulation of nociception, acting as a modulator of the interaction between TRPA1 and TRPV1, two molecular sensors and mediators of pain signals in dorsal root ganglia (DRG) neurons. Mechanistically, it weakens their interaction, thereby releasing the inhibition of TRPA1 by TRPV1 and increasing the single-channel open probability of the TRPA1-TRPV1 complex. [UniProt]
仅用于科研。不用于诊断过程。未经明确授权不得转售。
生物信息学
蛋白别名: Transmembrane protein 100
基因别名: TMEM100
UniProt ID: (Human) Q9NV29
Entrez Gene ID: (Human) 55273
angiogenesis
vasculogenesis
in utero embryonic development
epithelial to mesenchymal transition involved in endocardial cushion formation
Notch signaling pathway
BMP signaling pathway
protein kinase B signaling
positive regulation of endothelial cell differentiation
regulation of calcium-mediated signaling
regulation of sensory perception of pain
arterial endothelial cell differentiation
cellular response to BMP stimulus
positive regulation of vasculogenesis
