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A suggested positive control is rat brain tissue lysate.
PA5-20842 can be used with blocking peptide PEP-0956.
Calcium-activated chloride channels (CaCC) are present in many cell types and mediate physiological functions such as epithelial secretion, sensory signal transduction, and smooth muscle contraction. Subunits of these CaCC’s include the transmembrane proteins TMEM16A and TMEM16B. TMEM16B is predicted to have eight transmembrane domains with both the amino and carboxy termini in the cytoplasm and is expressed in several tissues including olfactory sensory neurons as well as photoreceptors in mammalian retina. Like TMEM16A, TMEM16B is thought to form at least part of CaCC’s but has different biophysical characteristics such as voltage dependence and unitary conductance.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
蛋白别名: ano2; anoctamin 2 isoform Adelta4; anoctamin 2 isoform Bdelta4; anoctamin 2, calcium activated chloride channel; anoctamin 2-like; Anoctamin-2; Transmembrane protein 16B; transmembrane protein 16B (eight membrane-spanning domains)
基因别名: ANO2; BC033409; C12orf3; TMEM16B
UniProt ID: (Human) Q9NQ90, (Mouse) Q8CFW1
Entrez Gene ID: (Human) 57101, (Mouse) 243634, (Rat) 100361584