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TNFRSF11B Antibody (PA5-34946) in IHC (P)
TNFRSF11B Polyclonal Antibody detects TNFRSF11B protein at cytosol on Cal27 xenograft by immunohistochemical analysis. Sample: Paraffin-embedded Cal27 xenograft. TNFRSF11B Polyclonal Antibody (Product # PA5-34946) dilution: 1:500. Antigen Retrieval: EDTA based buffer, pH 8.0, 15 min.
产品信息
PA5-34946
产品规格
种属反应
Human,
Mouse
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Synthetic peptide corresponding to a region within amino acids 1 and 67 of OPG
偶联物
形式
Liquid
浓度
1.85 mg/mL
纯化类型
Antigen affinity chromatography
保存液
PBS, pH 7, with 20% glycerol
内含物
0.025% ProClin 300
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Wet ice
RRID
AB_2552295
产品详细信息
Recommended positive controls: human plasma, TNFRSF11B-transfected 293T.
Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.
靶标信息
The protein encoded by this gene is a member of the TNF-receptor superfamily. This protein is an osteoblast-secreted decoy receptor that functions as a negative regulator of bone resorption. This protein specifically binds to its ligand, osteoprotegerin ligand, both of which are key extracellular regulators of osteoclast development. Studies of the mouse counterpart also suggest that this protein and its ligand play a role in lymph-node organogenesis and vascular calcification. Alternatively spliced transcript variants of this gene have been reported, but their full length nature has not been determined.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: MGC29565; Osteoclastogenesis inhibitory factor; Osteoprotegerin; soluble OPG; soluble Osteoprotegerin; sOPG; Tumor necrosis factor receptor superfamily member 11B; tumor necrosis factor receptor superfamily, member 11b
基因别名: OCIF; OPG; PDB5; TNFRSF11B; TR1
UniProt ID: (Human) O00300, (Mouse) O08712
Entrez Gene ID: (Human) 4982, (Mouse) 18383
skeletal system development
inflammatory response
immune response
signal transduction
response to nutrient
extracellular matrix organization
response to magnesium ion
response to lipopolysaccharide
tumor necrosis factor-mediated signaling pathway
regulation of cell proliferation
negative regulation of odontogenesis of dentin-containing tooth
response to drug
regulation of apoptotic process
positive regulation of MAPK cascade
response to estrogen
negative regulation of bone resorption
response to arsenic-containing substance
apoptotic signaling pathway
apoptotic process
