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TNFRSF11B Antibody (MA5-34922) in ICC/IF
Immunofluorescent analysis of Osteoprotegerin in MCF-7 cells (green). Samples were fixed in paraformaldehyde and permeabilised with 0.25% Triton X100/PBS, incubated with Osteoprotegerin monoclonal antibody (Product # MA5-34922), followed by DAPI (blue).
产品信息
MA5-34922
应用
建议稀释比
已发表文章
产品规格
种属反应
Human
宿主/亚型
Mouse
/ IgG1
分类
Monoclonal
类型
Antibody
克隆号
9C1
抗原
Recombinant protein within Human Osteoprotegerin aa 1-401
偶联物
形式
Liquid
浓度
2 mg/mL
纯化类型
Protein G
保存液
PBS, pH 7.4, with 50% glycerol, 0.2% BSA
内含物
0.05% sodium azide
保存条件
-20° C, Avoid Freeze/Thaw Cycles, store in dark
运输条件
Ambient (domestic); Wet ice (international)
RRID
AB_2848828
产品详细信息
Positive Control: K562, MCF-7, rat lung tissue, human liver tissue, human small intestine tissue, mouse heart tissue.
靶标信息
The protein encoded by this gene is a member of the TNF-receptor superfamily. This protein is an osteoblast-secreted decoy receptor that functions as a negative regulator of bone resorption. This protein specifically binds to its ligand, osteoprotegerin ligand, both of which are key extracellular regulators of osteoclast development. Studies of the mouse counterpart also suggest that this protein and its ligand play a role in lymph-node organogenesis and vascular calcification. Alternatively spliced transcript variants of this gene have been reported, but their full length nature has not been determined.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: MGC29565; Osteoclastogenesis inhibitory factor; Osteoprotegerin; soluble OPG; soluble Osteoprotegerin; sOPG; Tumor necrosis factor receptor superfamily member 11B; tumor necrosis factor receptor superfamily, member 11b
基因别名: OCIF; OPG; PDB5; TNFRSF11B; TR1
UniProt ID: (Human) O00300
Entrez Gene ID: (Human) 4982
skeletal system development
inflammatory response
immune response
signal transduction
response to nutrient
extracellular matrix organization
response to magnesium ion
response to lipopolysaccharide
tumor necrosis factor-mediated signaling pathway
regulation of cell proliferation
negative regulation of odontogenesis of dentin-containing tooth
response to drug
regulation of apoptotic process
positive regulation of MAPK cascade
response to estrogen
negative regulation of bone resorption
response to arsenic-containing substance
apoptotic signaling pathway
