Invitrogen

TRF2 Polyclonal Antibody

查看其他27个TRF2抗体

抗体检测数据 (3)

TRF2 Antibody in Immunohistochemistry (Paraffin) (IHC (P))

TRF2 Antibody in Immunohistochemistry (Paraffin) (IHC (P))

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TRF2 Antibody (PA5-80104) in IHC (P)

Immunohistochemistry analysis of TRF2 on paraffin-embedded human lung cancer tissue. Sample was incubated with TRF2 polyclonal antibody (Product# PA5-80104) with a dilution of 1 µg/mL, and developed by Streptavidin-Biotin-Complex (SABC) method.

TRF2 Antibody in Immunohistochemistry (Paraffin) (IHC (P))

TRF2 Antibody in Immunohistochemistry (Paraffin) (IHC (P))

TRF2 Antibody in Western Blot (WB)

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TRF2 Antibody in Immunohistochemistry (Paraffin) (IHC (P)) — Immunohistochemistry analysis of TRF2 on paraffin-embedded human lung cancer tissue. Sample was incubated with TRF2 polyclonal antibody (Product# PA5-80104) with a dilution of 1 µg/mL, and developed by Streptavidin-Biotin-Complex (SABC) method.

TRF2 Antibody in Immunohistochemistry (Paraffin) (IHC (P)) — Immunohistochemistry analysis of TRF2 on paraffin-embedded human tonsil tissue. Sample was incubated with TRF2 polyclonal antibody (Product# PA5-80104) with a dilution of 1 µg/mL, and developed by Streptavidin-Biotin-Complex (SABC) method.

TRF2 Antibody in Western Blot (WB) — Western blot analysis of TRF2 in rat thymus extract (lane 1) and COLO320 whole cell lysate (lane 2). Sample was incubated with TRF2 polyclonal antibody (Product # PA5-80104) at a dilution of 0.5 µg/mL. Signal development was performed using a chemiluminescence (ECL) kit.

产品信息

PA5-80104

应用

建议稀释比

已发表文章

免疫印迹 (WB)

0.1-0.5 µg/mL

-

免疫组化（石蜡） (IHC (P))

0.5-1 µg/mL

-

产品规格

种属反应

Human, Rat

宿主/亚型

Rabbit / IgG

分类

Polyclonal

类型

Antibody

抗原

E.coli-derived human TRF2 recombinant protein (Position: A81-K287).

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偶联物

Unconjugated Unconjugated Unconjugated

形式

Lyophilized

浓度

500 µg/mL

纯化类型

Antigen affinity chromatography

保存液

PBS with 4mg trehalose

内含物

0.05mg sodium azide

保存条件

-20°C

运输条件

Wet ice

RRID

AB_2747219

产品详细信息

Reconstitute with 0.2 mL of distilled water to yield a concentration of 500 µg/mL.

靶标信息

TRF2 is a ubiquitously expressed protein that is implicated in the control of telomere length. TRF2, like TRF1 contains a Myb-related DNA binding motif. It binds to duplex TTAGGG repeats and is localized to all human telomeres in metaphase chromosomes. TRF2 is thought to protect chromosome ends by maintaining the correct structure at telomere termini. The use of mutant forms of TRF2 has implicated a role for TRF2 in the prevention of senescence in primary human cells. Recently, it has been shown that inhibition of TRF2 resulted in apoptosis in a subset of mammalian cell types.

仅用于科研。不用于诊断过程。未经明确授权不得转售。

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引用该产品

生物信息学

蛋白别名: Telomeric DNA-binding protein; telomeric repeat binding protein 2; Telomeric repeat-binding factor 2; TTAGGG repeat-binding factor 2

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基因别名: TERF2; TRBF2; TRF2

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UniProt ID: (Human) Q15554

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Entrez Gene ID: (Human) 7014, (Rat) 361403

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double-stranded telomeric DNA binding telomerase activity protein binding protein C-terminus binding telomeric DNA binding protein homodimerization activity macromolecular complex binding G-rich strand telomeric DNA binding chromatin binding

参与通路

telomere maintenance in utero embryonic development positive regulation of gene expression negative regulation of gene expression obsolete telomere maintenance via telomere shortening telomere capping telomeric loop formation protection from non-homologous end joining at telomere negative regulation of telomere maintenance positive regulation of telomere maintenance positive regulation of nitric-oxide synthase activity protein localization to chromosome, telomeric region negative regulation of beta-galactosidase activity negative regulation of cellular senescence telomere maintenance via telomerase cell cycle regulation of telomere maintenance negative regulation of telomere maintenance via recombination regulation of telomere maintenance via telomerase negative regulation of telomere maintenance via semi-conservative replication cellular senescence negative regulation of telomere single strand break repair negative regulation of telomere capping negative regulation of t-circle formation