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Recommended positive controls: 293T, A431, Raji.
Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.
TRH-R is a 398 amino acid integral membrane protein with six transmembrane domains and belongs to G-protein coupled receptor 1 family. It acts as a receptor for the signaling hormone TRH and activates the inositol phospholipid-calcium-protein kinase C transduction pathway upon binding with TRH. Reports suggest that TRH-R is a neurotransmitter and neuro regulator that controls dimerization of the TRH receptor and potentiates hormone-induced receptor trafficking. It is known to widely express in the thyrotroph cells of the anterior pituitary.
⚠WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm. For more information go to www.P65Warnings.ca.gov.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
蛋白别名: MGC141920; Thyroliberin receptor; Thyrotropin-releasing hormone receptor; TRH receptor; TRH-R; TRH1 Receptor
基因别名: TRH-R; TRHR
UniProt ID: (Human) P34981, (Rat) Q01717
Entrez Gene ID: (Human) 7201, (Rat) 25570
分子生物学功能:
C4 zinc finger nuclear receptor
DNA-binding transcription factor
zinc finger transcription factor
gene-specific transcriptional regulator