Search Thermo Fisher Scientific
Percent identity with other species by BLAST analysis: Human, Gorilla, Gibbon, Monkey, Marmoset, Rat, Dog, Elephant, Horse (100%).
TRH-R is a 398 amino acid integral membrane protein with six transmembrane domains and belongs to G-protein coupled receptor 1 family. It acts as a receptor for the signaling hormone TRH and activates the inositol phospholipid-calcium-protein kinase C transduction pathway upon binding with TRH. Reports suggest that TRH-R is a neurotransmitter and neuro regulator that controls dimerization of the TRH receptor and potentiates hormone-induced receptor trafficking. It is known to widely express in the thyrotroph cells of the anterior pituitary.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
蛋白别名: MGC141920; Thyroliberin receptor; Thyrotropin-releasing hormone receptor; TRH receptor; TRH-R; TRH1 Receptor
基因别名: TRH-R; TRHR
UniProt ID: (Human) P34981, (Rat) Q01717
Entrez Gene ID: (Dog) 482007, (Human) 7201, (Horse) 100056618, (Rat) 25570
分子生物学功能: C4 zinc finger nuclear receptor DNA-binding transcription factor zinc finger transcription factor gene-specific transcriptional regulator