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产品信息
PA5-50851
产品规格
种属反应
Human,
Mouse
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Synthetic peptide corresponding to residues near the C terminal of human tribbles pseudokinase 1
偶联物
形式
Liquid
浓度
1.4 mg/mL
纯化类型
Antigen affinity chromatography
保存液
PBS, pH 7.4, with 40% glycerol
内含物
0.05% sodium azide
保存条件
-20°C
运输条件
Wet ice
RRID
AB_2636303
产品详细信息
The antibody detects endogenous levels of total TRIB1 protein.
靶标信息
TRIB1 also called gprotein coupled receptor induced, skip1, gig2, c8fwATP, functions in binding protein binding, protein kinase inhibitor activity, and protein serine/threonine kinase activities. Overexpression of TRIB1 in HeLa cells repressed the basal activity of the IL8 promoter by inhibiting AP1 activity. Overexpression of TRIB1 inhibited oncogenic Ras -driven AP1 activation and MEKK1-mediated AP1 activation. ERK activation was enhanced by TRIB1. Coimmunoprecipitation and yeast 2-hybrid assays showed that MEK1 interacted with both TRIB1 and TRIB3, and MKK4 interacted specifically with TRIB1. Cotransfection of MKK4 enhanced the level of TRIB1, indicating that the TRIB-MAPKK interaction stabilized TRIB1.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: G-protein-coupled receptor induced protein; G-protein-coupled receptor-induced gene 2 protein; G-protein-coupled receptor-induced protein 2; GIG-2; phosphoprotein regulated by mitogenic pathways; SKIP1; TRB-1; TRIB1; Tribbles homolog 1; tribbles-like protein 1
基因别名: A530090O15Rik; C8FW; GIG-2; GIG2; SKIP1; TRB-1; TRB1; TRIB1
UniProt ID: (Human) Q96RU8, (Mouse) Q8K4K4
Entrez Gene ID: (Human) 10221, (Mouse) 211770
protein kinase activity
protein kinase inhibitor activity
protein binding
ATP binding
transcription factor binding
mitogen-activated protein kinase kinase binding
ubiquitin protein ligase binding
ubiquitin-protein transferase regulator activity
transferase activity, transferring phosphorus-containing groups
non-receptor serine/threonine protein kinase
protein phosphorylation
negative regulation of protein kinase activity
JNK cascade
negative regulation of smooth muscle cell migration
negative regulation of lipopolysaccharide-mediated signaling pathway
positive regulation of proteasomal ubiquitin-dependent protein catabolic process
response to lipopolysaccharide
regulation of MAP kinase activity
negative regulation of sequence-specific DNA binding transcription factor activity
positive regulation of eosinophil differentiation
positive regulation of macrophage differentiation
negative regulation of neutrophil differentiation
negative regulation of smooth muscle cell proliferation
regulation of catalytic activity
positive regulation of ubiquitin-protein transferase activity
