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TRIB1 Antibody (MA5-26721) in IHC (P)
Immunohistochemistry was performed on paraffin-embedded adenocarcinoma of human colon tissue. To expose target proteins, 1 mM EDTA in 10mM Tris, pH8.5, 120°C for 3min was used. Following antigen retrieval, tissues were probed with a TRIB1 monoclonal antibody (Product # MA5-26721).
产品信息
MA5-26721
产品规格
种属反应
Human
宿主/亚型
Mouse
/ IgG1
分类
Monoclonal
类型
Antibody
克隆号
OTI8C8
抗原
Full length human recombinant protein of TRIB1 produced in HEK293T cell
偶联物
形式
Liquid
浓度
1 mg/mL
纯化类型
Affinity Chromatography
保存液
PBS, pH 7.3, with 1% BSA, 50% glycerol
内含物
0.02% sodium azide
保存条件
-20° C, Avoid Freeze/Thaw Cycles
运输条件
Ambient (domestic); Wet ice (international)
RRID
AB_2723728
靶标信息
TRIB1 also called gprotein coupled receptor induced, skip1, gig2, c8fwATP, functions in binding protein binding, protein kinase inhibitor activity, and protein serine/threonine kinase activities. Overexpression of TRIB1 in HeLa cells repressed the basal activity of the IL8 promoter by inhibiting AP1 activity. Overexpression of TRIB1 inhibited oncogenic Ras -driven AP1 activation and MEKK1-mediated AP1 activation. ERK activation was enhanced by TRIB1. Coimmunoprecipitation and yeast 2-hybrid assays showed that MEK1 interacted with both TRIB1 and TRIB3, and MKK4 interacted specifically with TRIB1. Cotransfection of MKK4 enhanced the level of TRIB1, indicating that the TRIB-MAPKK interaction stabilized TRIB1.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: G-protein-coupled receptor induced protein; G-protein-coupled receptor-induced gene 2 protein; G-protein-coupled receptor-induced protein 2; GIG-2; phosphoprotein regulated by mitogenic pathways; SKIP1; TRB-1; TRIB1; Tribbles homolog 1; tribbles-like protein 1
基因别名: C8FW; GIG-2; GIG2; SKIP1; TRB-1; TRB1; TRIB1
UniProt ID: (Human) Q96RU8
Entrez Gene ID: (Human) 10221
protein phosphorylation
negative regulation of protein kinase activity
JNK cascade
negative regulation of smooth muscle cell migration
negative regulation of lipopolysaccharide-mediated signaling pathway
positive regulation of proteasomal ubiquitin-dependent protein catabolic process
response to lipopolysaccharide
regulation of MAP kinase activity
negative regulation of sequence-specific DNA binding transcription factor activity
positive regulation of eosinophil differentiation
positive regulation of macrophage differentiation
negative regulation of neutrophil differentiation
negative regulation of smooth muscle cell proliferation
