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Invitrogen
TRIM27 Polyclonal Antibody
高级验证
This Antibody was verified by Relative expression to ensure that the antibody binds to the antigen stated.
产品信息
PA5-65785
产品规格
种属反应
Human
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
偶联物
形式
Liquid
浓度
0.1 mg/mL
纯化类型
Antigen affinity chromatography
保存液
PBS, pH 7.2, with 40% glycerol
内含物
0.02% sodium azide
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Wet ice
RRID
AB_2662570
产品详细信息
Immunogen sequence: DIGDTLSRAER IRIPEPWITP PDLQEKIHIF AQKCLFLTES LKQFTEKMQS DMEKIQELRE AQLYSVDV
Highest antigen sequence identity to the following orthologs - mouse 100%, rat 100%.
靶标信息
This gene encodes a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. This protein localizes to the nuclear matrix. It interacts with the enhancer of polycomb protein and represses gene transcription. It is also thought to be involved in the differentiation of male germ cells. Fusion of the N-terminus of this protein with the truncated C-terminus of the RET gene product has been shown to result in production of the ret transforming protein.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: Ret finger protein; RFP transforming protein; RING finger protein 76; tripartite motif protein TRIM27; tripartite motif-containing 27; Tripartite motif-containing protein 27; Zinc finger protein RFP
基因别名: RFP; RNF76; TRIM27
UniProt ID: (Human) P14373
Entrez Gene ID: (Human) 5987
negative regulation of transcription from RNA polymerase II promoter
negative regulation of adaptive immune response
transcription, DNA-templated
negative regulation of protein kinase activity
spermatogenesis
cell proliferation
peptidyl-tyrosine phosphorylation
negative regulation of tumor necrosis factor production
negative regulation of viral transcription
Arp2/3 complex-mediated actin nucleation
retrograde transport, endosome to Golgi
innate immune response
negative regulation of gene expression, epigenetic
positive regulation of sequence-specific DNA binding transcription factor activity
positive regulation of actin nucleation
protein trimerization
protein K63-linked ubiquitination
interferon-gamma secretion
negative regulation of calcium ion import
negative regulation of interleukin-2 secretion
negative regulation of viral release from host cell
