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TRIM27 Antibody (PA5-90911) in IHC (P)
Immunohistochemistry analysis of TRIM27 in paraffin-embedded mouse kidney. Samples were incubated with TRIM27 Polyclonal antibody (Product # PA5-90911) using a dilution of 1:100 (40x lens). Perform microwave antigen retrieval with 10 mM PBS buffer pH 7.2 before commencing with IHC staining protocol.
产品信息
PA5-90911
产品规格
种属反应
Human,
Mouse,
Rat
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Recombinant fusion protein containing a sequence corresponding to amino acids 1-200 of human TRIM27 (NP_0065011)
偶联物
形式
Liquid
浓度
0.79 mg/mL
纯化类型
Affinity Chromatography
保存液
PBS, pH 7.3, with 50% glycerol
内含物
0.01% thimerosal
保存条件
-20° C, Avoid Freeze/Thaw Cycles
运输条件
Wet ice
RRID
AB_2806287
产品详细信息
Immunogen sequence: MASGSVAECL QQETTCPVCL QYFAEPMMLD CGHNICCACL ARCWGTAETN VSCPQCRETF PQRHMRPNRH LANVTQLVKQ LRTERPSGPG GEMGVCEKHR EPLKLYCEED QMPICVVCDR SREHRGHSVL PLEEAVEGFK EQIQNQLDHL KRVKDLKKRR RAQGEQARAE LLSLTQMERE KIVWEFEQLY HSLKEHEYRL; Positive Samples: HeLa, HepG2, Raji, SH-SY5Y; Cellular Location: Cytoplasm, Early endosome, Nucleus, PML body
靶标信息
This gene encodes a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. This protein localizes to the nuclear matrix. It interacts with the enhancer of polycomb protein and represses gene transcription. It is also thought to be involved in the differentiation of male germ cells. Fusion of the N-terminus of this protein with the truncated C-terminus of the RET gene product has been shown to result in production of the ret transforming protein.
⚠WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm. For more information go to www.P65Warnings.ca.gov.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: Ret finger protein; ret finger protein 1; RFP transforming protein; RING finger protein 76; tripartite motif protein 27; tripartite motif protein TRIM27; tripartite motif-containing 27; Tripartite motif-containing protein 27; Zinc finger protein RFP
基因别名: AW538890; Gm19403; RFP; Rfp1; RNF76; TRIM27
UniProt ID: (Human) P14373, (Mouse) Q62158
Entrez Gene ID: (Human) 5987, (Mouse) 19720, (Rat) 291171
nucleic acid binding
DNA binding
transmembrane receptor protein tyrosine kinase activity
ubiquitin-protein transferase activity
protein binding
zinc ion binding
ligase activity
identical protein binding
metal ion binding
UDP-N-acetylmuramoylalanyl-D-glutamyl-2,6-diaminopimelate-D-alanyl-D-alanine ligase activity
ribosomal S6-glutamic acid ligase activity
coenzyme F420-0 gamma-glutamyl ligase activity
coenzyme F420-2 alpha-glutamyl ligase activity
protein-glycine ligase activity
protein-glycine ligase activity, initiating
protein-glycine ligase activity, elongating
tubulin-glycine ligase activity
protein-glutamic acid ligase activity
tubulin-glutamic acid ligase activity
ubiquitin-protein ligase
negative regulation of transcription from RNA polymerase II promoter
negative regulation of adaptive immune response
transcription, DNA-templated
negative regulation of protein kinase activity
spermatogenesis
cell proliferation
peptidyl-tyrosine phosphorylation
negative regulation of tumor necrosis factor production
negative regulation of viral transcription
Arp2/3 complex-mediated actin nucleation
retrograde transport, endosome to Golgi
innate immune response
negative regulation of gene expression, epigenetic
positive regulation of sequence-specific DNA binding transcription factor activity
positive regulation of actin nucleation
protein trimerization
protein K63-linked ubiquitination
interferon-gamma secretion
negative regulation of calcium ion import
negative regulation of interleukin-2 secretion
negative regulation of viral release from host cell
regulation of transcription, DNA-templated
transport
