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TRIM32 Monoclonal Antibody (2E5)

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实验方案
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产品信息

H00022954-M09

应用
建议稀释比
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免疫印迹 (WB)

1-5 µg/mL
-

免疫细胞化学 (ICC/IF)

10-100 µg/mL
-

酶联免疫吸附实验 (ELISA)

10 µg/mL
-

功能检测 (Functional)

1-5 µg/mL
-
产品规格

种属反应

Human

宿主/亚型

Mouse / IgG2a, kappa

分类

Monoclonal

类型

Antibody

克隆号

2E5

抗原

TRIM32 (NP_036342, 105 a.a. approximately 204 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
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偶联物

Unconjugated Unconjugated Unconjugated

形式

Liquid

浓度

1 mg/mL

纯化类型

Protein A

保存液

PBS, pH 7.4

内含物

no preservative

保存条件

-20° C, Avoid Freeze/Thaw Cycles

运输条件

Wet ice

产品详细信息

Product may be used with Western Blot (Transfected lysate).

Immunogen sequence: RRLPRQFCRS CGLVLCEPCR EADHQPPGHC TLPVKEAAEE RRRDFGEKLT RLRELMGELQ RRKAALEGVS KDLQARYKAV LQEYGHEERR VQDELARSRK

靶标信息

TRIM32 is a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. TRIM32 localizes to cytoplasmic bodies. The protein has also been localized to the nucleus, where it interacts with the activation domain of the HIV-1 Tat protein. The Tat protein activates transcription of HIV-1 genes.

仅用于科研。不用于诊断过程。未经明确授权不得转售。

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生物信息学

蛋白别名: 72 kDa Tat-interacting protein; E3 ubiquitin-protein ligase TRIM32; RING-type E3 ubiquitin transferase TRIM32; RP11-67K19.1; TAT-interactive protein, 72-KD; tripartite motif-containing 32; Tripartite motif-containing protein 32; Zinc finger protein HT2A; zinc-finger protein HT2A

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基因别名: BBS11; HT2A; LGMD2H; TATIP; TRIM32

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UniProt ID: (Human) Q13049

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Entrez Gene ID: (Human) 22954

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功能
transcription coactivator activity RNA binding ubiquitin-protein transferase activity protein binding zinc ion binding ligase activity myosin binding Tat protein binding translation initiation factor binding ubiquitin binding protein self-association ubiquitin protein ligase activity
参与通路
protein polyubiquitination tissue homeostasis actin ubiquitination response to UV protein ubiquitination positive regulation of cell growth positive regulation of cell migration regulation of type I interferon production negative regulation of viral transcription response to tumor necrosis factor protein ubiquitination involved in ubiquitin-dependent protein catabolic process positive regulation of I-kappaB kinase/NF-kappaB signaling innate immune response fat cell differentiation positive regulation of neuron differentiation positive regulation of protein catabolic process positive regulation of cell cycle positive regulation of proteolysis muscle cell cellular homeostasis negative regulation of fibroblast proliferation positive regulation of neurogenesis positive regulation of sequence-specific DNA binding transcription factor activity positive regulation of NF-kappaB transcription factor activity positive regulation of striated muscle cell differentiation axon development negative regulation of viral release from host cell negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage positive regulation of tumor necrosis factor-mediated signaling pathway positive regulation of interleukin-17-mediated signaling pathway positive regulation of chemokine (C-C motif) ligand 20 production positive regulation of cell motility
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