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产品信息
PA5-22802
产品规格
种属反应
Fruit fly,
Human,
Mouse,
Rat
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Synthetic peptide of residues 239-250, which is a 100% conserved region of human, mouse, rat and Drosophila Alien.
偶联物
形式
Liquid
浓度
1 mg/mL
纯化类型
Antigen affinity chromatography
保存液
PBS
内含物
0.02% sodium azide
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Ambient (domestic); Wet ice (international)
RRID
AB_11152187
产品详细信息
Suggested positive control: antigen standard for COPS2 (transient overexpression lysate).
靶标信息
Isocitrate dehydrogenases catalyze the oxidative decarboxylation of isocitrate to 2-oxoglutarate. These enzymes belong to two distinct subclasses, one of which utilizes NAD(+) as the electron acceptor and the other NADP(+). Five isocitrate dehydrogenases have been reported: three NAD(+)-dependent isocitrate dehydrogenases, which localize to the mitochondrial matrix, and two NADP(+)-dependent isocitrate dehydrogenases, one of which is mitochondrial and the other predominantly cytosolic. NAD(+)-dependent isocitrate dehydrogenases catalyze the allosterically regulated rate-limiting step of the tricarboxylic acid cycle. Each isozyme is a heterotetramer that is composed of two alpha subunits, one beta subunit, and one gamma subunit. The protein encoded by this gene is the beta subunit of one isozyme of NAD(+)-dependent isocitrate dehydrogenase. Three alternatively spliced transcript variants encoding different isoforms have been described for this gene.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: Alien homolog; Alien protein; alien-like; alien-PA; alien-PB; alien-PD; alien-PE; CG9556-PA; CG9556-PB; CG9556-PD; CG9556-PE; COP9; COP9 (constitutive photomorphogenic) homolog, subunit 2; COP9 complex homolog subunit 2; COP9 constitutive photomorphogenic homolog subunit 2; COP9 signalosome complex subunit 2; d-Alien; Dch2; drosophila COP9 signalosome homolog 2; JAB1-containing signalosome subunit 2; SD08021p; SGN2; signalosome subunit 2; thyroid receptor interacting protein 15; Thyroid receptor-interacting protein 15; TR-interacting protein 15; TRIP-15; tyroid receptor interacting protein 15
基因别名: AI315723; ALIEN; BcDNA:LD10463; C85265; CG9556; CH2; COPS2; CSN2; DCH2; Dmel\CG9556; Dmel_CG9556; SGN2; TRIP-15; TRIP15
UniProt ID: (Human) P61201, (Mouse) P61202, (Rat) P61203, (Fruit fly) Q94899
Entrez Gene ID: (Human) 9318, (Mouse) 12848, (Rat) 261736, (Fruit fly) 34225
negative regulation of transcription from RNA polymerase II promoter
nucleotide-excision repair, DNA damage recognition
transcription-coupled nucleotide-excision repair
transcription from RNA polymerase II promoter
signal transduction
cell proliferation
cullin deneddylation
neuron differentiation
skeletal muscle cell differentiation
negative regulation of nucleic acid-templated transcription
negative regulation of transcription, DNA-templated
protein deneddylation
multicellular organism development
germ cell development
female germ-line stem cell population maintenance
male germ-line cyst encapsulation
germarium-derived cystoblast division
protein stabilization
