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产品信息
PA1-46473
产品规格
种属反应
Mouse,
Rat
已发表种属
Mouse
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Synthetic peptide corresponding to residues 1200-1300 of an internal portion of mouse TRPM2. [Swiss-Prot# Q91YD4]
偶联物
形式
Liquid
浓度
1.5 mg/mL
纯化类型
Antigen affinity chromatography
保存液
PBS with 30% glycerol
内含物
0.1% sodium azide
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Wet ice
RRID
AB_2272268
产品详细信息
Suggested positive control: mouse brain membrane protein.
靶标信息
TRPM2 belongs to the ion transport protein family which includes Sodium, Potassium, Calcium ion channels. This family is characterized by proteins possessing 6 transmembrane helices in which the last two helices flank a loop which determines ion selectivity. TRPM2 is activated by oxidative stress and confers susceptibility to cell death. Further, TRPM2 is a calcium-permeable cation channel that is regulated by free intracellular ADP-ribose. Several alternatively spliced transcript variants of the TRPM2 gene have been described, but their full-length nature is not known.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
生物信息学
蛋白别名: EC 3.6.1.13; EREG 1; KNP 3; Long transient receptor potential channel 2; LTRPC 2; LTrpC-2; MGC133383; null; Transient receptor potential cation channel subfamily M member 2; Transient receptor potential channel 7; transient receptor potential melastatin family 2; transient receptor protein 7; TRPC 7; TrpC7; TRPM 2
基因别名: 9830168K16Rik; C79133; LTRPC2; Trp7; TRPC7; Trpm2; Trpm2-predicted; Trrp7
UniProt ID: (Rat) E9PTA2, (Mouse) Q91YD4
Entrez Gene ID: (Rat) 294329, (Mouse) 28240
manganese ion transport
metabolic process
response to hydroperoxide
manganese ion transmembrane transport
transport
ion transport
cation transport
sodium ion transport
calcium ion transport
response to oxidative stress
positive regulation of insulin secretion
ion transmembrane transport
transmembrane transport
calcium ion transmembrane transport
calcium ion import across plasma membrane
positive regulation of oxidative stress-induced neuron death
