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TRPM8 Antibody (MA5-35474) in WB
Western blot analysis of TRPM8 in extracts of various cell lines. Samples were incubated with TRPM8 Monoclonal antibody (Product # MA5-35474) using a dilution of 1:1,000, followed by HRP Goat Anti-Rabbit IgG (H+L) at a dilution of 1:10,000. Lysates/proteins: 25 µg per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit. Exposure time: 3 min.
产品信息
MA5-35474
产品规格
种属反应
Human
已发表种属
Not Applicable
宿主/亚型
Rabbit
/ IgG
Expression System
HEK293 cells
分类
Recombinant Monoclonal
类型
Antibody
克隆号
ARC0947
抗原
A synthetic peptide corresponding to a sequence within amino acids 900-1000 of human TRPM8 (Q7Z2W7)
偶联物
形式
Liquid
浓度
0.8 mg/mL
纯化类型
Affinity Chromatography
保存液
PBS, pH 7.3, with 50% glycerol, 0.05% BSA
内含物
0.02% sodium azide
保存条件
-20° C, Avoid Freeze/Thaw Cycles
运输条件
Ambient (domestic); Wet ice (international)
RRID
AB_2849375
产品详细信息
Immunogen sequence: FRSVIYEPYL AMFGQVPSDV DGTTYDFAHC TFTGNESKPL CVELDEHNLP RFPEWITIPL VCIYMLSTNI LLVNLLVAMF GYTVGTVQEN NDQVWKFQRY F
靶标信息
TRPM8 is a receptor-activated non-selective cation channel involved in detection of sensations such as coolness, by being activated by cold temperature below 25 degrees Celsius. TRPM8 is activated by icilin, eucalyptol, menthol, cold and modulation of intracellular pH and involved in menthol sensation. TRPM8 is permeable for monovalent cations sodium, potassium, and cesium and divalent cation calcium. TRPM8 has an expression pattern within normal human tissues that is mostly restricted to prostate epithelial cells. TRPM8 mRNA expression is at moderate levels in normal prostate tissue and appears to be elevated in prostate cancer. Notably, TRPM8 mRNA was also expressed in a number of nonprostatic primary tumors of breast, colon, lung, and skin origin, whereas transcripts encoding TRPM8 were hardly detected or not detected in the corresponding normal human tissues.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
生物信息学
蛋白别名: Long transient receptor potential channel 6; LTrpC-6; MGC2849; short form of the TRPM8 cationic channel; transient receptor melastatin 8 variant 1; transient receptor melastatin 8 variant 2; Transient receptor potential cation channel subfamily M member 8; transient receptor potential cation channel, subfamily M, member 8; Transient receptor potential p8; transient receptor potential subfamily M member 8; Trp-p8
基因别名: LTRPC6; TRPM8; TRPP8
UniProt ID: (Human) Q7Z2W7
Entrez Gene ID: (Human) 79054
