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TRPM8 (extracellular) Antibody (ACC-049-200UL) in ICC/IF
Expression of TRPM8 in rat DRG cells - Immunocytochemistry of rat dorsal root ganglion (DRG) cells. A. Intracellular staining of cells with Anti-TRPM8 (extracellular) Antibody (#ACC-049), (1:500) followed by goat Anti-rabbit-AlexaFluor-555 secondary Antibody . B. Extracellular staining of live cells with Anti-TRPM8 (extracellular) Antibody (1:50) followed by goat Anti-rabbit-AlexaFluor-555 secondary Antibod... View More
产品信息
ACC-049-200UL
产品规格
种属反应
Human,
Mouse,
Rat
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
SDVDGTTYDFAHC,corresponding to amino acid residues 917-929 of human TRPM8, 3rd extracellular loop
偶联物
形式
Lyophilized
浓度
0.8 mg/mL
纯化类型
Antigen affinity chromatography
保存液
PBS, pH 7.4, with 1% BSA
内含物
0.05% sodium azide
保存条件
-20° C, Avoid Freeze/Thaw Cycles
运输条件
Ambient (domestic); Wet ice (international)
产品详细信息
Reconstitution: 25 µL, 50 µL or 0.2 mL double distilled water (DDW), depending on the sample size. The antibody ships as a lyophilized powder at room temperature. Upon arrival, it should be stored at -20C. The reconstituted solution can be stored at 4C for up to 1 week. For longer periods, small aliquots should be stored at -20C. Avoid multiple freezing and thawing. Centrifuge all antibody preparations before use (10000 x g 5 min).
靶标信息
TRPM8 is a receptor-activated non-selective cation channel involved in detection of sensations such as coolness, by being activated by cold temperature below 25 degrees Celsius. TRPM8 is activated by icilin, eucalyptol, menthol, cold and modulation of intracellular pH and involved in menthol sensation. TRPM8 is permeable for monovalent cations sodium, potassium, and cesium and divalent cation calcium. TRPM8 has an expression pattern within normal human tissues that is mostly restricted to prostate epithelial cells. TRPM8 mRNA expression is at moderate levels in normal prostate tissue and appears to be elevated in prostate cancer. Notably, TRPM8 mRNA was also expressed in a number of nonprostatic primary tumors of breast, colon, lung, and skin origin, whereas transcripts encoding TRPM8 were hardly detected or not detected in the corresponding normal human tissues.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: Cold menthol receptor 1; cold/menthol receptor 1; Long transient receptor potential channel 6; LTrpC-6; MGC2849; short form of the TRPM8 cationic channel; transient receptor melastatin 8 variant 1; transient receptor melastatin 8 variant 2; Transient receptor potential cation channel subfamily M member 8; transient receptor potential cation channel, subfamily M, member 8; Transient receptor potential p8; transient receptor potential subfamily M member 8; transient receptor potential-p8; TRP ion channel TRPM8; Trp-p8
基因别名: CMR1; LTrpC-6; LTRPC6; Trp-p8; TRPM8; TRPP8
UniProt ID: (Human) Q7Z2W7, (Rat) Q8R455, (Mouse) Q8R4D5
Entrez Gene ID: (Human) 79054, (Rat) 171384, (Mouse) 171382
cellular calcium ion homeostasis
response to cold
detection of temperature stimulus
thermoception
protein homotetramerization
protein homotrimerization
calcium ion transmembrane transport
calcium ion transport
response to temperature stimulus
transport
ion transport
cation transport
ion transmembrane transport
response to stimulus
sensory perception of temperature stimulus
transmembrane transport
