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Immunogen sequence: TPLPSLRVEA EAGGSGARTP PLSRRKAVDM RLRMELGAPE EMGQVPPLDS RPSSPALYFT HDASLVHKSP DPFGAVAAQK FSLAHSMLAI SGHLDSDDDS GSGSLVGIDN KIEQAMDLVK SHLMF
Highest antigen sequence identity to the following orthologs: Mouse - 82%, Rat - 82%.
TSC22D4 is a member of the TSC22 domain family of leucine zipper transcriptional regulators. Gene Ontology (GO) annotations related to this gene include DNA-binding transcription factor activity. An important paralog of this gene is TSC22D1.
Binds DNA and acts as a transcriptional repressor (PubMed:10488076). Involved in the regulation of systematic glucose homeostasis and insulin sensitivity, via transcriptional repression of downstream insulin signaling targets such as OBP2A/LCN13 (By similarity). Acts as a negative regulator of lipogenic gene expression in hepatocytes and thereby mediates the control of very low-density lipoprotein release (PubMed:23307490). May play a role in neurite elongation and survival (By similarity).
仅用于科研。不用于诊断过程。未经明确授权不得转售。
蛋白别名: tsc-22-like protein THG-1; TSC22 domain family protein 4; TSC22 domain family, member 4; TSC22-related-inducible leucine zipper protein 2
基因别名: THG-1; THG1; THG1-PIT; TILZ2; TSC22D4
UniProt ID: (Human) Q9Y3Q8
Entrez Gene ID: (Human) 81628