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This target displays homology in the following species: Cow: 79%; Dog: 77%; Guinea Pig: 92%; Horse: 86%; Human: 92%; Mouse: 100%; Pig: 93%; Rabbit: 86%; Rat: 100%
TSC22D4 is a member of the TSC22 domain family of leucine zipper transcriptional regulators. Gene Ontology (GO) annotations related to this gene include DNA-binding transcription factor activity. An important paralog of this gene is TSC22D1.
Binds DNA and acts as a transcriptional repressor (PubMed:10488076). Involved in the regulation of systematic glucose homeostasis and insulin sensitivity, via transcriptional repression of downstream insulin signaling targets such as OBP2A/LCN13 (By similarity). Acts as a negative regulator of lipogenic gene expression in hepatocytes and thereby mediates the control of very low-density lipoprotein release (PubMed:23307490). May play a role in neurite elongation and survival (By similarity).
仅用于科研。不用于诊断过程。未经明确授权不得转售。
蛋白别名: TSC22 domain family 4; TSC22 domain family protein 4; TSC22-related inducible leucine zipper 2; TSC22-related-inducible leucine zipper protein 2
基因别名: 0610009M14Rik; 1700023B23Rik; AI415410; Thg-1pit; Thg1-pit; Tilz2; Tsc22d4
UniProt ID: (Mouse) Q9EQN3
Entrez Gene ID: (Mouse) 78829