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TSH Receptor (TSHR) (extracellular) Antibody (ATR-006-200UL) in IHC (F)
Expression of TSH Receptor in mouse hippocampus. Immunohistochemical staining of perfusion-fixed frozen mouse brain sections with Anti-TSH Receptor (TSHR) (extracellular) Antibody (#ATR-006), (1:200), followed by goat Anti-rabbit-AlexaFluor-488. A. Staining in the hippocampal CA3 region, showed immunoreactivity (green) in the pyramidal layer (P, arrows) and in mossy fiber terminal region (MF). B. Pre-incuba... View More
产品信息
ATR-006-200UL
产品规格
种属反应
Human,
Mouse,
Rat
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
ETLQAFDSHYDYTVC, corresponding to amino acid residues 376-390 of rat TSHR, Extracellular, N-terminus
偶联物
形式
Lyophilized
浓度
0.85 mg/mL
纯化类型
Antigen affinity chromatography
保存液
PBS, pH 7.4, with 1% BSA
内含物
0.05% sodium azide
保存条件
-20° C, Avoid Freeze/Thaw Cycles
运输条件
Ambient (domestic); Wet ice (international)
产品详细信息
Reconstitution: 25 µL, 50 µL or 0.2 mL double distilled water (DDW), depending on the sample size. The antibody ships as a lyophilized powder at room temperature. Upon arrival, it should be stored at -20C. The reconstituted solution can be stored at 4C for up to 1 week. For longer periods, small aliquots should be stored at -20C. Avoid multiple freezing and thawing. Centrifuge all antibody preparations before use (10000 x g 5 min).
靶标信息
TSH Receptor gene is a membrane protein and a major controller of thyroid cell metabolism. The encoded protein is a receptor for thyrothropin and thyrostimulin, and its activity is mediated by adenylate cyclase. Defects in this gene are a cause of several types of hyperthyroidism. Three transcript variants encoding different isoforms have been found for this gene.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: MGC141920; seven transmembrane helix receptor; thyroid stimulating hormone receptor, isoform 2; Thyroid-stimulating hormone receptor; Thyrotropin receptor; thyrotropin receptor-I, hTSHR-I; TSH-R
基因别名: AI481368; CHNG1; hTSHR-I; hypothroid; hyt; LGR3; pet; TSHR; TSHRA
UniProt ID: (Human) P16473, (Mouse) P47750, (Rat) P21463
Entrez Gene ID: (Human) 7253, (Mouse) 22095, (Rat) 25360
G-protein coupled receptor signaling pathway
G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger
adenylate cyclase-activating G-protein coupled receptor signaling pathway
activation of adenylate cyclase activity
cell-cell signaling
nervous system development
positive regulation of cell proliferation
hormone-mediated signaling pathway
thyroid-stimulating hormone signaling pathway
signal transduction
adult locomotory behavior
B cell differentiation
regulation of locomotion
positive regulation of multicellular organism growth
inner ear receptor cell development
inner ear receptor stereocilium organization
dopaminergic neuron differentiation
cochlea morphogenesis
