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产品信息
PA5-19088
产品规格
种属反应
Mouse
宿主/亚型
Goat
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Synthetic peptide sequence (RDNSGRRGGSRLPE) corresponding to the C-terminus amino acids of Tspo (aa 156-169).
偶联物
形式
Liquid
浓度
0.5 mg/mL
纯化类型
Ammonium sulfate precipitation
保存液
TBS, pH 7.3, with 0.5% BSA
内含物
0.02% sodium azide
保存条件
-20° C, Avoid Freeze/Thaw Cycles
运输条件
Wet ice
RRID
AB_10979487
产品详细信息
This antibody is predicted to react with rat based on sequence homology.
This antibody is tested in Peptide ELISA: antibody detection limit dilution 128,000.
靶标信息
Mitochondrial peripheral-type benzodiazepine receptor (PBR) is an indispensable element of the steroidogenic machinery, where it mediates the delivery of cholesterol to the inner mitochondrial side chain cleavage cytochrome P-450 upon ligand activation. PBR is composed of three subunits, an isoquinoline binding site, a voltage-dependent anion channel and an adenine nucleotide carrier. PBR is genetically conserved from bacteria to humans and in humans is widely expressed in peripheral organs, whereas in the brain, it is sparse and located mainly in glial cells. Peroxisome proliferator perfluordecanoic acid (PFDA) inhibits the Leydig cell steroidogenesis by affecting PBR mRNA stability, thus inhibiting PBR expression, cholesterol transport into the mitochondria and subsequent steroid formation. A cytoplasmic protein, PRAX-1 ( peripheral benzodiazepine receptor-associated protein 1), is found to specifically interact with PBR.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: benzodiazepine receptor, peripheral; isoquinoline-binding protein; Mitochondrial benzodiazepine receptor; OTTHUMP00000028891; PBR; Peripheral-type benzodiazepine receptor; PKBS; Translocator protein
基因别名: Bzrp; IBP; Mbr; PBR; Tspo; Tspo1
UniProt ID: (Mouse) P50637
Entrez Gene ID: (Mouse) 12257
steroid biosynthetic process
transport
ion transport
chloride transport
lipid transport
signal transduction
chemical synaptic transmission
glial cell migration
positive regulation of necrotic cell death
negative regulation of tumor necrosis factor production
positive regulation of apoptotic process
negative regulation of nitric oxide biosynthetic process
behavioral response to pain
regulation of steroid biosynthetic process
positive regulation of mitochondrial depolarization
positive regulation of calcium ion transport
contact inhibition
positive regulation of glial cell proliferation
negative regulation of glial cell proliferation
positive regulation of reactive oxygen species metabolic process
