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Talizumab Chimeric Antibody (MA5-42310) in SDS-PAGE
SDS-PAGE analysis of the recombinant IgE protein expressed in CHO cells using a Talizumab biosimilar monoclonal antibody (Product # MA5-42310). R denotes the lane was run under reducing conditions. NR denotes the lane was run under non-reducing conditions.
产品信息
MA5-42310
产品规格
种属反应
Human
宿主/亚型
Human
/ IgG4, kappa/IgG4, lambda
Expression System
CHO cells
分类
Recombinant Monoclonal
类型
Antibody
抗原
IgE
偶联物
形式
Liquid
浓度
1.18 mg/mL
纯化类型
Protein A
保存液
PBS, pH 7.4
内含物
no preservative
保存条件
-20° C, Avoid Freeze/Thaw Cycles
运输条件
Ambient (domestic); Wet ice (international)
RRID
AB_2911452
产品详细信息
Endotoxin level < 0.01EU/µg by LAL method
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8 °C for one week. Store at -20 to -80 °C for twelve months from the date of receipt.
靶标信息
Talizumab is a biosimilar that targets IgE. IgE is one of the five classes of immunoglobulins found in mammals. Monomers consist of two heavy (epsilon) chains with 4 Ig-like constant domains, and two light chains. IgE plays an essential role in type I hypersensitivity (allergic responses such as hay fever, asthma, hives, anaphylatic shock) by binding to Fc receptors on basophils and mast cells. Crosslinking of IgE bound to Fc receptors induces degranulation of mast cells and basophils that promote allergic manifestations. IgE is also functionally important for immunity against parasites.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: AL-90; C21; HU-901; Hu901; TNX-901
