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产品信息
MA1-43019
产品规格
种属反应
Human
宿主/亚型
Mouse
/ IgG1
分类
Monoclonal
类型
Antibody
克隆号
5020
抗原
Human Thrombin.
偶联物
形式
Liquid
浓度
7.8 mg/mL
纯化类型
SDS-PAGE
保存液
50% water with 50% glycerol
内含物
no preservative
保存条件
-20° C, Avoid Freeze/Thaw Cycles
运输条件
Ambient (domestic); Wet ice (international)
RRID
AB_1087796
产品详细信息
MA1-43019 detects Thrombin in human samples.
MA1-43019 has successfully been used in ELISA applications.
MA1-43019 is specific to human thrombin, thrombin-ATIII complex and thrombin-PPACK.
靶标信息
Coagulation factor II is proteolytically cleaved to form thrombin in the first step of the coagulation cascade which ultimately results in the stemming of blood loss. F2 also plays a role in maintaining vascular integrity during development and postnatal life. Mutations in F2 leads to various forms of thrombosis and dysprothrombinemia.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: Coagulation factor II; coagulation factor II (thrombin); prepro-coagulation factor II; Prothombin; Prothrombin; prothrombin B-chain; serine protease
基因别名: F2; PT; RPRGL2; THPH1
UniProt ID: (Human) P00734
Entrez Gene ID: (Human) 2147
positive regulation of protein phosphorylation
signal peptide processing
proteolysis
ER to Golgi vesicle-mediated transport
acute-phase response
cell surface receptor signaling pathway
multicellular organism development
blood coagulation
blood coagulation, intrinsic pathway
positive regulation of cell proliferation
regulation of cell shape
response to wounding
regulation of gene expression
negative regulation of platelet activation
positive regulation of phosphatidylinositol 3-kinase signaling
response to inactivity
peptidyl-glutamic acid carboxylation
platelet activation
regulation of blood coagulation
positive regulation of blood coagulation
positive regulation of cell growth
positive regulation of collagen biosynthetic process
fibrinolysis
cellular protein metabolic process
negative regulation of proteolysis
negative regulation of astrocyte differentiation
leukocyte migration
positive regulation of release of sequestered calcium ion into cytosol
regulation of cytosolic calcium ion concentration
negative regulation of fibrinolysis
cellular response to mechanical stimulus
positive regulation of phospholipase C-activating G-protein coupled receptor signaling pathway
positive regulation of reactive oxygen species metabolic process
