NeoBiotechnologies

Thymidylate Synthase (5-FU Resistance Marker) Monoclonal Antibody (TS106)

Thymidylate Synthase (5-FU Resistance Marker) Antibody in Immunohistochemistry (Paraffin) (IHC (P))

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Thymidylate Synthase (5-FU Resistance Marker) Antibody (7298-MSM1-P0) in IHC (P)

Formalin-fixed, paraffin-embedded human testicular carcinoma stained with Thymidylate Synthase Mouse Monoclonal Antibody (TS106).

Thymidylate Synthase (5-FU Resistance Marker) Antibody in SDS-PAGE (SDS-PAGE)

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产品信息

7298-MSM1-P0

应用

建议稀释比

已发表文章

免疫组化（石蜡） (IHC (P))

Assay-dependent

免疫组织化学（多聚甲醛固定） (IHC (PFA))

1-2 µg/mL

免疫细胞化学 (ICC/IF)

0.5-1 µg/mL

流式细胞分析 (Flow)

0.5-1 µg/10^6 cells

产品规格

种属反应

Human

宿主/亚型

Mouse / IgG1, kappa

分类

Monoclonal

类型

Antibody

克隆号

TS106

抗原

Recombinant full-length human TYMS protein.

查看免疫原

偶联物

Unconjugated Unconjugated Unconjugated

形式

Liquid

浓度

200 µg/mL

纯化类型

Protein A/G

保存液

PBS, pH 7.4, with 0.05% BSA

内含物

0.05% sodium azide

保存条件

4° C, do not freeze

运输条件

Wet ice

靶标信息

Thymidylate Synthase (TS) converts deoxyuridine monophosphate (dUMP) to deoxythymidine monophosphate (dTMP), which is essential for DNA biosynthesis. TS is a critical target for the fluoropyrimidines, an important group of antineoplastic drugs that are widely used in the treatment of solid tumors. Both 5-FU and fluorodeoxyuridine are converted in tumor cells to FdUMP which inactivates TS by formation of a ternary covalent complex in the presence of the folate cofactor 5,10-methylenetetrahydrofolate. Expression of TS protein is associated with response to 5-fluorouracil (5-FU) in human colorectal, gastric, head and neck, and breast carcinomas.

仅用于科研。不用于诊断过程。未经明确授权不得转售。