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TrkA Antibody (PA5-120786) in IHC (P)
Immunohistochemistry analysis of TrkA in paraffin-embedded rat cerebellum. Samples were incubated with TrkA Polyclonal antibody (Product # PA5-120786) using a dilution of 1:100 (40x lens). Perform microwave antigen retrieval with 10 mM PBS buffer pH 7.2 before commencing with IHC staining protocol.
产品信息
PA5-120786
产品规格
种属反应
Human,
Mouse,
Rat
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Recombinant fusion protein containing a sequence corresponding to amino acids 1-280 of human TrkA (NP_002520.2).
偶联物
形式
Liquid
浓度
1 mg/mL
纯化类型
Affinity Chromatography
保存液
PBS, pH 7.3, with 50% glycerol
内含物
0.02% sodium azide
保存条件
-20° C, Avoid Freeze/Thaw Cycles
运输条件
Wet ice
RRID
AB_2914358
产品详细信息
Positive test controls include: HeLa, K-562, NIH/3T3, Mouse liver, Mouse heart, Rat liver. The target is usually found in the following locations: Cell membrane, Early endosome membrane, Late endosome membrane, Single-pass type I membrane protein.
Immunogen sequence: MLRGGRRGQL GWHSWAAGPG SLLAWLILAS AGAAPCPDAC CPHGSSGLRC TRDGALDSLH HLPGAENLTE LYIENQQHLQ HLELRDLRGL GELRNLTIVK SGLRFVAPDA FHFTPRLSRL NLSFNALESL SWKTVQGLSL QELVLSGNPL HCSCALRWLQ RWEEEGLGGV PEQKLQCHGQ GPLAHMPNAS CGVPTLKVQV PNASVDVGDD VLLRCQVEGR GLEQAGWILT ELEQSATVMK SGGLPSLGLT LANVTSDLNR KNVTCWAEND VGRAEVSVQV
靶标信息
NTRK1 (TRKA) belongs to the neurotrophic factor family of related polypeptides central to the development and maintenance of the mammalian nervous system. TrkA is a membrane-bound receptor that, upon neurotrophin binding, phosphorylates itself and members of the MAPK pathway. The presence of TrkA leads to cell differentiation and may play a role in specifying sensory neuron subtypes. Mutations in TrkA have been associated with congenital insensitivity to pain, anhidrosis, self-mutilating behavior, mental retardation and cancer.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: DKFZp781I14186; EC 2.7.10.1; gp140trk; High affinity nerve growth factor receptor; kinase TrkA; Neurotrophic tyrosine kinase receptor type 1; neurotrophic tyrosine kinase, receptor, type 1; Oncogene TRK; p140-TrkA; Slow nerve growth factor receptor; trk; Trk-A; TRK1-transforming tyrosine kinase protein; TrkA neurotrophin receptor; trkA proto-oncogene receptor; Tropomyosin-related kinase A; Tyrosine kinase receptor; Tyrosine kinase receptor A
基因别名: C80751; MTC; NTRK1; p140-TrkA; Tkr; TRK; Trk-A; TRK1; TRKA
UniProt ID: (Human) P04629, (Mouse) Q3UFB7, (Rat) P35739
Entrez Gene ID: (Human) 4914, (Mouse) 18211, (Rat) 59109
transmembrane receptor protein tyrosine kinase activity
GPI-linked ephrin receptor activity
neurotrophin p75 receptor binding
protein binding
ATP binding
nerve growth factor receptor activity
kinase binding
protein homodimerization activity
neurotrophin binding
nerve growth factor binding
nucleotide binding
protein kinase activity
protein tyrosine kinase activity
neurotrophin receptor activity
kinase activity
transferase activity
transferase activity, transferring phosphorus-containing groups
ephrin receptor binding
transmembrane signal receptor
activation of MAPKK activity
positive regulation of protein phosphorylation
protein phosphorylation
microtubule-based movement
axon guidance
aging
learning or memory
circadian rhythm
negative regulation of cell proliferation
response to radiation
programmed cell death involved in cell development
positive regulation of neuron projection development
response to activity
peptidyl-tyrosine phosphorylation
olfactory nerve development
B cell differentiation
response to nutrient levels
nerve growth factor signaling pathway
mechanoreceptor differentiation
response to drug
positive regulation of programmed cell death
negative regulation of neuron apoptotic process
positive regulation of GTPase activity
response to ethanol
positive regulation of Ras protein signal transduction
protein autophosphorylation
neurotrophin TRK receptor signaling pathway
ephrin receptor signaling pathway
phosphatidylinositol-mediated signaling
sympathetic nervous system development
response to axon injury
detection of temperature stimulus involved in sensory perception of pain
detection of mechanical stimulus involved in sensory perception of pain
positive regulation of NF-kappaB transcription factor activity
response to hydrostatic pressure
response to electrical stimulus
positive regulation of synapse assembly
positive regulation of synaptic transmission, glutamatergic
Sertoli cell development
axonogenesis involved in innervation
behavioral response to formalin induced pain
positive regulation of ERK1 and ERK2 cascade
cellular response to nicotine
cellular response to nerve growth factor stimulus
transmembrane receptor protein tyrosine kinase signaling pathway
multicellular organism development
nervous system development
phosphorylation
sensory perception of pain
cell differentiation
response to nicotine
positive regulation of angiogenesis
innervation
cellular response to growth factor stimulus
negative regulation of neuron death
