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TrxR1 Antibody (PA5-116094) in IHC (P)
Immunohistochemistry analysis of TrxR1 in mouse colorectal tissue. Samples were treated with formaldehyde and treated with citrate buffer for antigen retrieval, blocked, and incubated (1.5 hours at 22°C) with polyclonal antibody (Product # PA5-116094) at a dilution of 1:100. Secondary staining was applied with HRP conjugated anti-Rabbit.
产品信息
PA5-116094
产品规格
种属反应
Human,
Mouse,
Rat
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
A synthesized peptide derived from human TXNRD1(Accession Q16881), corresponding to amino acid residues Y302-D323.
偶联物
形式
Liquid
浓度
1 mg/mL
纯化类型
Affinity chromatography
保存液
PBS with 50% glycerol
内含物
0.02% sodium azide
保存条件
-20°C
运输条件
Wet ice
RRID
AB_2900728
产品详细信息
Antibody detects endogenous levels of total TXNRD1.
靶标信息
This gene encodes a member of the family of pyridine nucleotide oxidoreductases. This protein reduces thioredoxins as well as other substrates, and plays a role in selenium metabolism and protection against oxidative stress. The functional enzyme is thought to be a homodimer which uses FAD as a cofactor. Each subunit contains a selenocysteine (Sec) residue which is required for catalytic activity. The selenocysteine is encoded by the UGA codon that normally signals translation termination. The 3' UTR of selenocysteine-containing genes have a common stem-loop structure, the sec insertion sequence (SECIS), that is necessary for the recognition of UGA as a Sec codon rather than as a stop signal. Alternative splicing results in several transcript variants encoding the same or different isoforms.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: gene associated with retinoic and IFN-induced mortality 12 protein; Gene associated with retinoic and interferon-induced mortality 12 protein; GRIM-12; KM-102-derived reductase-like factor; MGC9145; NADPH-dependent thioredoxin reductase; oxidoreductase; Peroxidase TXNRD1; selenoprotein oxidoreductase; testis tissue sperm-binding protein Li 46a; Thioredoxin reductase 1, cytoplasmic; thioredoxin reductase GRIM-12; Thioredoxin reductase TR1; TR; TR alpha
基因别名: GRIM-12; GRIM12; KDRF; TR; TR1; TRXR1; TXNR; TXNRD1
UniProt ID: (Human) Q16881, (Mouse) Q9JMH6
Entrez Gene ID: (Human) 7296, (Rat) 58819, (Mouse) 50493
thioredoxin-disulfide reductase activity
protein binding
electron carrier activity
protein disulfide oxidoreductase activity
flavin adenine dinucleotide binding
methylselenol reductase activity
methylseleninic acid reductase activity
mercury (II) reductase activity
NAD(P)H oxidase activity
selenate reductase activity
protein homodimerization activity
mercury ion binding
NADP binding
oxidoreductase activity
oxidoreductase activity, acting on a sulfur group of donors, NAD(P) as acceptor
reductase
response to reactive oxygen species
mesoderm formation
selenium compound metabolic process
signal transduction
cell proliferation
nucleobase-containing small molecule interconversion
cell redox homeostasis
oxidation-reduction process
cellular oxidant detoxification
placenta development
glutathione metabolic process
response to oxidative stress
gastrulation
response to selenium ion
positive regulation of cell death
selenocysteine metabolic process
methylmercury metabolic process
response to drug
benzene-containing compound metabolic process
hydrogen peroxide catabolic process
response to axon injury
detoxification of mercury ion
protein tetramerization
response to hyperoxia
halogen metabolic process
NADPH oxidation
cellular response to copper ion
cellular response to hyperoxia
