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产品信息
PA5-36998
产品规格
种属反应
Human,
Mouse,
Rat
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Synthetic peptide corresponding to amino acids 613-658 of human UBAP2L
偶联物
形式
Liquid
浓度
1 mg/mL
纯化类型
Antigen affinity chromatography
保存液
PBS, pH 7.2, with 50% glycerol
内含物
0.02% sodium azide
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Wet ice
RRID
AB_2553856
产品详细信息
This antibody detects endogenous protein at a molecular weight of 115 kDa.
Purity is >95% by SDS-PAGE.
靶标信息
NICE4, also known as UBAP2L (Ubiquitin-associated protein 2-like) orKIAA0144, is a 1,087 amino acid protein that is ubiquitously expressed. Phosphorylated upon DNA damage, NICE4 contains one UBA domain and is expressed as 4 isoforms produced by alternative splicing events. The gene that encodes NICE4 maps to human chromosome 1. Chromosome 1 is the largest human chromosome spanning about 260 million base pairs and making up 8% of the human genome. There are about 3,000 genes on chromosome 1, and considering the great number of genes there are also a large number of diseases associated with chromosome 1. Notably, the rare aging disease Hutchinson-Gilford progeria is associated with the LMNA gene which encodes Lamin A. When defective, the LMNA gene product can build up in the nucleus and cause characteristic nuclear blebs. The mechanism of rapidly enhanced aging is unclear and is a topic of continuing exploration. The MUTYH gene is located on chromosome 1 and is partially responsible for familial adenomatous polyposis. Stickler syndrome, Parkinsons, Gaucher disease and Usher syndrome are also associated with chromosome 1.
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生物信息学
蛋白别名: Nice-4 protein homolog; Protein NICE-4; RNA polymerase II degradation factor UBAP2L; ubiquitin associated protein 2-like; Ubiquitin-associated protein 2-like
基因别名: 3110083O19Rik; 4932431F02Rik; A430103N23Rik; C77168; EP1; KIAA0144; mKIAA0144; NICE-4; NICE4; UBAP2L
UniProt ID: (Human) Q14157, (Mouse) Q80X50
Entrez Gene ID: (Rat) 361984, (Human) 9898, (Mouse) 74383
