Abnova

UBTF Monoclonal Antibody (2C6)

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UBTF Antibody (H00007343-M05) in WB

UBTF monoclonal antibody (M05), clone 2C6. Western Blot analysis of UBTF expression in PC-12.

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产品信息

H00007343-M05

应用

建议稀释比

已发表文章

免疫印迹 (WB)

1-5 µg/mL

酶联免疫吸附实验 (ELISA)

10 µg/mL

产品规格

种属反应

Human, Rat

宿主/亚型

Mouse / IgG1, kappa

分类

Monoclonal

类型

Antibody

克隆号

2C6

抗原

UBTF (NP_055048, 551 a.a. approximately 650 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.

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偶联物

Unconjugated Unconjugated Unconjugated

形式

Liquid

浓度

0.5 mg/mL

纯化类型

Protein A

保存液

PBS, pH 7.4

内含物

no preservative

保存条件

-20° C, Avoid Freeze/Thaw Cycles

运输条件

Wet ice

产品详细信息

Product may be used with Western Blot (Cell lysate).

Immunogen sequence: PPAATNSSKK MKFQGEPKKP PMNGYQKFSQ ELLSNGELNH LPLKERMVEI GSRWQRISQS QKEHYKKLAE EQQKQYKVHL DLWVKSLSPQ DRAAYKEYIS

靶标信息

UBF-1 encodes a member of the HMG-box DNA-binding protein family. The encoded protein plays a critical role in ribosomal RNA transcription as a key component of the pre-initiation complex, mediating the recruitment of RNA polymerase I to rDNA promoter regions. The encoded protein may also play important roles in chromatin remodeling and pre-rRNA processing, and its activity is regulated by both phosphorylation and acetylation. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. Pseudogenes of this gene are located on the short arm of chromosomes 3, 11 and X and the long arm of chromosome 11.

仅用于科研。不用于诊断过程。未经明确授权不得转售。

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引用该产品

生物信息学

蛋白别名: 90-kDa nucleolus organizer region autoantigen; Autoantigen NOR-90; NOR90; Nucleolar transcription factor 1; transcription factor UBF; UBF-1; Upstream-binding factor 1

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基因别名: NOR-90; Tcfubf; UBF; UBF-1; UBF1; UBF2; UBTF

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UniProt ID: (Human) P17480, (Rat) P25977

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Entrez Gene ID: (Human) 7343, (Rat) 25574

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功能

RNA polymerase I CORE element sequence-specific DNA binding RNA polymerase I upstream control element sequence-specific DNA binding protein binding poly(A) RNA binding DNA binding chromatin binding DNA-binding transcription factor

参与通路

regulation of transcription from RNA polymerase I promoter transcription from RNA polymerase I promoter transcription initiation from RNA polymerase I promoter transcription elongation from RNA polymerase I promoter termination of RNA polymerase I transcription positive regulation of transcription from RNA polymerase I promoter regulation of glucose mediated signaling pathway chromatin silencing at rDNA chromatin remodeling regulation of transcription, DNA-templated