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产品信息
PA5-142610
产品规格
种属反应
Human
宿主/亚型
Goat
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Peptide with sequence PLRDVAAKGSC.
偶联物
形式
Liquid
浓度
0.5 mg/mL
纯化类型
Ammonium sulfate precipitation
保存液
TBS, pH 7.3, with 0.5% BSA
内含物
0.02% sodium azide
保存条件
-20° C, Avoid Freeze/Thaw Cycles
运输条件
Wet ice
RRID
AB_2933256
产品详细信息
Additional Information: This antibody is expected to recognize all reported isoforms (NP_074053.1; NP_001036044.1).
This antibody is tested in Peptide ELISA: antibody detection limit dilution 1:64,000.
靶标信息
Plays a role in vesicle maturation during exocytosis as a target of the diacylglycerol second messenger pathway. Is involved in neurotransmitter release by acting in synaptic vesicle priming prior to vesicle fusion and participates in the activity-depending refilling of readily releasable vesicle pool (RRP). Essential for synaptic vesicle maturation in a subset of excitatory/glutamatergic but not inhibitory/GABA-mediated synapses.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: homolog of rat Munc13 (diacylglycerol-binding); munc13; Munc13-2; Protein unc-13 homolog B
基因别名: MUNC13; UNC13; UNC13B; Unc13h2
UniProt ID: (Human) O14795
Entrez Gene ID: (Human) 10497
apoptotic process
signal transduction
chemical synaptic transmission
neurotransmitter secretion
neuromuscular junction development
excretion
positive regulation of synaptic vesicle priming
glutamate secretion
synaptic vesicle docking
synaptic vesicle priming
synaptic transmission, glutamatergic
intracellular signal transduction
regulation of short-term neuronal synaptic plasticity
innervation
positive regulation of inhibitory postsynaptic potential
