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产品信息
PA5-90699
应用
建议稀释比
已发表文章
产品规格
种属反应
Human,
Mouse
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Recombinant fusion protein containing a sequence corresponding to amino acids 1-350 of human UNC13B (NP_0063683)
偶联物
形式
Liquid
浓度
0.46 mg/mL
纯化类型
Affinity Chromatography
保存液
PBS, pH 7.3, with 50% glycerol
内含物
0.01% thimerosal
保存条件
-20° C, Avoid Freeze/Thaw Cycles
运输条件
Wet ice
RRID
AB_2806185
产品详细信息
Immunogen sequence: MSLLCVRVKR AKFQGSPDKF NTYVTLKVQN VKSTTVAVRG DQPSWEQDFM FEISRLDLGL SVEVWNKGLI WDTMVGTVWI ALKTIRQSDE EGPGEWSTLE AETLMKDDEI CGTRNPTPHK ILLDTRFELP FDIPEEEARY WTYKWEQINA LGADNEYSSQ EESQRKPLPT AAAQCSFEDP DSAVDDRDSD YRSETSNSFP PPYHTASQPN ASVHQFPVPV RSPQQLLLQG SSRDSCNDSM QSYDLDYPER RAISPTSSSR YGSSCNVSQG SSQLSELDQY HEQDDDHRET DSIHSCHSSH SLSRDGQAGF GEQEKPLEVT GQAEKEAACE PKEMKEDATT HPPPDLVLQK; Positive Samples: 293T, LO2; Cellular Location: Cell junction, Cell membrane, Cytoplasm, Membrane, Peripheral membrane protein, synapse
靶标信息
Plays a role in vesicle maturation during exocytosis as a target of the diacylglycerol second messenger pathway. Is involved in neurotransmitter release by acting in synaptic vesicle priming prior to vesicle fusion and participates in the activity-depending refilling of readily releasable vesicle pool (RRP). Essential for synaptic vesicle maturation in a subset of excitatory/glutamatergic but not inhibitory/GABA-mediated synapses.
⚠WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm. For more information go to www.P65Warnings.ca.gov.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: homolog of rat Munc13 (diacylglycerol-binding); munc13; Munc13-2; Protein unc-13 homolog B; UNC-13 homolog 1; unc-13 homolog A; unc13 homolog 1
基因别名: MUNC13; Munc13-1; Munc13-2; UNC13; Unc13a; UNC13B; Unc13h1; Unc13h2
UniProt ID: (Human) O14795, (Mouse) Q9Z1N9
Entrez Gene ID: (Human) 10497, (Mouse) 22249
apoptotic process
signal transduction
chemical synaptic transmission
neurotransmitter secretion
neuromuscular junction development
excretion
positive regulation of synaptic vesicle priming
glutamate secretion
synaptic vesicle docking
synaptic vesicle priming
synaptic transmission, glutamatergic
intracellular signal transduction
regulation of short-term neuronal synaptic plasticity
innervation
positive regulation of inhibitory postsynaptic potential
exocytosis
spontaneous neurotransmitter secretion
