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产品信息
PA5-20510
应用
建议稀释比
已发表文章
产品规格
种属反应
Human,
Mouse,
Rat
已发表种属
Mouse
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
A 19 amino acid peptide from near the amino terminus of human Unc93b.
偶联物
形式
Liquid
浓度
1 mg/mL
纯化类型
Antigen affinity chromatography
保存液
PBS
内含物
0.02% sodium azide
保存条件
Maintain refrigerated at 2-8°C for up to 3 months. For long term storage store at -20°C
运输条件
Ambient (domestic); Wet ice (international)
RRID
AB_11152747
产品详细信息
A suggested positive control is human heart tissue lysate.
PA5-20510 can be used with blocking peptide PEP-0630.
靶标信息
The endoplasmic reticulum (ER) protein Unc93b, a human homolog of the C. elegans Unc93 gene, was initially identified by a forward genetic screen using N-ethyl-N-nitrosourea where a histidine-to-arginine substitution in Unc93b caused defects in Toll-like receptor (TLR) 3, 7 and 9 signaling. Unlike Unc93a, another homolog of the C. elegans Unc93 gene whose function is unknown, Unc93b specifically interacts with TLR3, 7 and 9; the histidine-to-arginine point mutation used to identify Unc93b abolishes this interaction. Mice carrying this point mutation are highly susceptible to infection with a number of viruses, indicating that Unc93b plays an important role in innate immunity.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
生物信息学
蛋白别名: hUNC93B1; Protein unc-93 homolog B1; unc-93 homolog B; unc-93 related protein; Unc-93B1; unc93 homolog B; unc93 homolog B1
基因别名: IIAE1; Unc-93B1; UNC93; UNC93B; UNC93B1
UniProt ID: (Human) Q9H1C4, (Mouse) Q3TNR9
Entrez Gene ID: (Human) 81622, (Rat) 361689, (Mouse) 54445
toll-like receptor signaling pathway
intracellular protein transport
biological_process
antigen processing and presentation of exogenous peptide antigen via MHC class II
toll-like receptor 3 signaling pathway
toll-like receptor 7 signaling pathway
toll-like receptor 9 signaling pathway
immune system process
innate immune response
defense response to virus
adaptive immune response
