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UPAR Antibody (A304-463A) in WB
Detection of human glycosylated and deglycosylated UPAR by western blot of immunoprecipitates. Samples: Whole cell lysate (0.5 or 1.0 mg per IP reaction; 20% of IP loaded) from U-937 cells incubated with (+) or without (-) TPA (200nM, 72 hrs) and lysed using NETN lysis buffer. The lysate was then treated (+) or mock treated (-) with PnGase F. Antibodies: Affinity purified rabbit anti-UPAR antibody A304-462A (lot A304-462A-1) used for IP at 6 µg per reaction. For blotting immunoprecipitated UPAR, A304-463A was used at 1... View More
产品信息
A304-463A
产品规格
种属反应
Human
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Region between residue 175 to 225 of Human Urokinase-Type Plasminogen Activator (uPA) Receptor.
偶联物
形式
Liquid
浓度
1 mg/mL
纯化类型
Antigen affinity chromatography
保存液
tris citrate/phosphate, pH 7-8
内含物
0.09% sodium azide
保存条件
4° C
运输条件
Wet ice
产品详细信息
The recommended shelf life for this product is 1 year from date of receipt.
Based on 100% sequence identity, this antibody is predicted to react with Chimpanzee
靶标信息
The urokinase-type plasminogen activator receptor is a key molecule in the regulation of cell-surface plasminogen activation and plays an important role in many normal as well as pathologic processes. The human PLAUR cDNA encodes 335 amino acids including a predicted signal peptide of 22 residues and a hydrophobic C-terminal portion. It produces a highly glycosylated protein of about 50 kD in monocytes where it is anchored to the plasma membrane by glycosyl-phosphatidylinositol linkage. PLAUR, also known as UPAR, is directly associated with the carbohydrate-binding domain of SELL in the membrane of neutrophils, an association analogous to that between PLAUR and beta-2 integrins. PLAUR-mediated calcium mobilization is SELL dependent. UPAR mRNA levels correlate with the invasive potential of endometrial carcinomas and show a 33-fold increase in UPAR mRNA levels in advanced clinical stage endometrial tumors compared with normal endometrial tissue. Furthermore, the increase in UPAR mRNA levels correlated linearly with the progression of disease stage. UPAR protein expressioin correlated positively with rate of recurrence and mortality in patients with endometrial cancer. UPAR appears to be a useful prognostic marker for advanced endometrial cancer.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: CD87; Monocyte activation antigen Mo3; sCD87; soluble CD87; U-PAR; u-plasminogen activator receptor form 2; Urokinase plasminogen activator surface receptor; urokinase-type plasminogen activator (uPA) receptor
基因别名: CD87; MO3; PLAUR; U-PAR; UPAR; URKR
UniProt ID: (Human) Q03405
Entrez Gene ID: (Human) 5329
positive regulation of protein phosphorylation
movement of cell or subcellular component
chemotaxis
signal transduction
blood coagulation
attachment of GPI anchor to protein
regulation of proteolysis
urokinase plasminogen activator signaling pathway
fibrinolysis
negative regulation of apoptotic process
positive regulation of DNA binding
positive regulation of epidermal growth factor receptor signaling pathway
positive regulation of release of cytochrome c from mitochondria
negative regulation of intrinsic apoptotic signaling pathway
negative regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway
