Search Thermo Fisher Scientific
Disclaimer
Clicking the images or links will redirect you to a website hosted by BenchSci that provides third-party scientific content. Neither the content nor the BenchSci technology and processes for selection have been evaluated by us; we are providing them as-is and without warranty of any kind, including for use or application of the Thermo Fisher Scientific products presented.
图: 1 / 5
UVRAG Antibody (PA5-97066) in IHC (P)
Immunohistochemistry analysis of UVRAG in paraffin-embedded mouse spinal cord. Samples were incubated with UVRAG Polyclonal antibody (Product # PA5-97066) using a dilution of 1:100 (40x lens). Perform microwave antigen retrieval with 10 mM PBS buffer pH 7.2 before commencing with IHC staining protocol.
产品信息
PA5-97066
产品规格
种属反应
Human,
Mouse,
Rat
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Recombinant fusion protein containing a sequence corresponding to amino acids 501-699 of human UVRAG (NP_0033602)
偶联物
形式
Liquid
浓度
0.49 mg/mL
纯化类型
Affinity Chromatography
保存液
PBS, pH 7.3, with 50% glycerol
内含物
0.02% sodium azide
保存条件
-20° C, Avoid Freeze/Thaw Cycles
运输条件
Wet ice
RRID
AB_2808868
产品详细信息
Immunogen sequence: KGHRKRASSE NERLQYKTPP PSYNSALAQP VTTVPSMGET ERKITSLSSS LDTSLDFSKE NKKKGEDLVG SLNGGHANVH PSQEQGEALS GHRATVNGTL LPSEQAGSAS VQLPGEFHPV SEAELCCTVE QAEEIIGLEA TGFASGDQLE AFNCIPVDSA VAVECDEQVL GEFEEFSRRI YALNENVSSF RRPRRSSDK; Positive Samples: LO2, HeLa, Mouse liver, Rat liver, Rat brain; Cellular Location: Chromosome, Early endosome, Endoplasmic reticulum, Late endosome, Lysosome, Midbody, centromere
靶标信息
UVRAG is predicted to contain a coiled-coil structure and is likely to be metabolically unstable based on the occurrence of a strong PEST domain. It interacts with Beclin 1, leading to activation of autophagy and thereof inhibition of tumorigenicity of human colon cancer cells. The gene for UVRAG protein is localized on human chromosome 11q13. 5 and complements the ultraviolet sensitivity of xeroderma pigmentosum group C cells. The gene has been extremely well conserved during evolution, implying an important role for this gene product in cell metabolism. Chromosomal aberrations involving this gene are associated with left-right axis malformation, and mutations in this gene have been associated with colon cancer. The protein is highly expressed in human brain, lung, kidney and liver.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
篇参考文献 (0)
您是否在文献中引用过该产品？请点击下方按钮邮件告知我们。
生物信息学
蛋白别名: beclin 1 binding protein; disrupted in heterotaxy; p63; UV radiation resistance-associated gene protein; UV radiation resistance-associated protein
基因别名: 9530039D02Rik; AI648770; BB124205; DHTX; p63; UVRAG; Uvrag1; Uvragl; VPS38
UniProt ID: (Human) Q9P2Y5, (Mouse) Q8K245
Entrez Gene ID: (Human) 7405, (Rat) 308846, (Mouse) 78610
DNA repair
retrograde vesicle-mediated transport, Golgi to ER
autophagy
spindle organization
chromosome segregation
positive regulation of autophagy
regulation of cytokinesis
receptor catabolic process
SNARE complex assembly
viral entry into host cell
centrosome organization
maintenance of Golgi location
regulation of vesicle-mediated transport
regulation of protein serine/threonine kinase activity
multivesicular body sorting pathway
autophagosome maturation
double-strand break repair via classical nonhomologous end joining
biological_process
