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产品信息
PA5-104192
产品规格
种属反应
Human,
Mouse,
Rat
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
A synthesized peptide derived from human UBQLN2(Accession Q9UHD9), corresponding to amino acid residues S527-N577.
偶联物
形式
Liquid
浓度
1 mg/mL
纯化类型
Affinity chromatography
保存液
PBS, pH 7.4, with 50% glycerol
内含物
0.02% sodium azide
保存条件
-20°C
运输条件
Wet ice
RRID
AB_2853520
产品详细信息
Antibody detects endogenous levels of total UBQLN2.
靶标信息
This gene encodes an ubiquitin-like protein (ubiquilin) that shares high degree of similarity with related products in yeast, rat and frog. Ubiquilins contain a N-terminal ubiquitin-like domain and a C-terminal ubiquitin-associated domain. They physically associate with both proteasomes and ubiquitin ligases; and thus, are thought to functionally link the ubiquitination machinery to the proteasome to affect in vivo protein degradation. This ubiquilin has also been shown to bind the ATPase domain of the Hsp70-like Stch protein.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: Chap1; DSK2 homolog; Nedd4 binding protein 4; PLIC-2; Protein linking IAP with cytoskeleton 2; Ubiquilin-2; Ubiquitin-like product Chap1/Dsk2; Ubiquitin-related protein
基因别名: ALS15; CHAP1; DSK2; HRIHFB2157; N4BP4; Plic-2; PLIC2; RGD1563566; UBQLN2
UniProt ID: (Human) Q9UHD9, (Mouse) Q9QZM0
Entrez Gene ID: (Human) 29978, (Mouse) 54609, (Rat) 317396
regulation of macroautophagy
ER-associated ubiquitin-dependent protein catabolic process
negative regulation of clathrin-mediated endocytosis
positive regulation of ER-associated ubiquitin-dependent protein catabolic process
negative regulation of G-protein coupled receptor internalization
regulation of autophagosome assembly
autophagy
