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Invitrogen
Ubiquilin 2 Monoclonal Antibody (3B8A10)
高级验证
This Antibody was verified by Cell treatment to ensure that the antibody binds to the antigen stated.
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Ubiquilin 2 Antibody (35-4400) in ICC/IF
Immunofluorescence analysis of Dsk2 Monoclonal Antibody (3B8A10) was performed using 70% confluent log phase SH-SY5Y cells treated with 1 uM Nocodazole for 12 h. The cells were fixed with 4% paraformaldehyde for 10 minutes, permeabilized with 0.1% Triton™ X-100 for 10 minutes, and blocked with 1% BSA for 1 hour at room temperature. The cells were labeled with Dsk2 (3B8A10) Mouse Monoclonal Antibody at 2 µg/... View More
产品信息
35-4400
应用
建议稀释比
已发表文章
产品规格
种属反应
Human
已发表种属
Human,
Mouse
宿主/亚型
Mouse
/ IgG1
分类
Monoclonal
类型
Antibody
克隆号
3B8A10
抗原
Recombinant protein corresponding to the C-terminal region of the human ubiquilin protein
偶联物
形式
Liquid
浓度
0.5 mg/mL
纯化类型
Protein A
保存液
PBS, pH 7.4
内含物
0.1% sodium azide
保存条件
-20°C
运输条件
Ambient (domestic); Wet ice (international)
RRID
AB_2533204
靶标信息
This gene encodes an ubiquitin-like protein (ubiquilin) that shares high degree of similarity with related products in yeast, rat and frog. Ubiquilins contain a N-terminal ubiquitin-like domain and a C-terminal ubiquitin-associated domain. They physically associate with both proteasomes and ubiquitin ligases; and thus, are thought to functionally link the ubiquitination machinery to the proteasome to affect in vivo protein degradation. This ubiquilin has also been shown to bind the ATPase domain of the Hsp70-like Stch protein.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
生物信息学
蛋白别名: Chap1; DSK2 homolog; Nedd4 binding protein 4; PLIC-2; Protein linking IAP with cytoskeleton 2; Ubiquilin-2; Ubiquitin-like product Chap1/Dsk2
基因别名: ALS15; CHAP1; DSK2; HRIHFB2157; N4BP4; PLIC2; UBQLN2
UniProt ID: (Human) Q9UHD9
Entrez Gene ID: (Human) 29978
autophagy
regulation of macroautophagy
ER-associated ubiquitin-dependent protein catabolic process
negative regulation of clathrin-mediated endocytosis
positive regulation of ER-associated ubiquitin-dependent protein catabolic process
negative regulation of G-protein coupled receptor internalization
regulation of autophagosome assembly
