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Urocortin Antibody (PA5-75189) in IHC (P)
Immunohistochemistry analysis of Urocortin in paraffin-embedded human colorectal carcinoma tissue. Samples were incubated with Urocortin polyclonal antibody (Product # PA5-75189) at a dilution of 1:100.
产品信息
PA5-75189
产品规格
种属反应
Human,
Mouse,
Rat
已发表种属
Human
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Synthetic peptide corresponding to amino acids 80-124 of Human UCN.
偶联物
Unconjugated
形式
Liquid
浓度
1 mg/mL
纯化类型
Antigen affinity chromatography
保存液
PBS, pH 7.2, with 50% glycerol
内含物
0.02% sodium azide
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Ambient (domestic); Wet ice (international)
RRID
AB_2718917
产品详细信息
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
靶标信息
Urocortin (UCN), a 40 amino acids neuropeptide widely distributed in the central nervous system (CNS), belongs to a family of structurally related peptides including corticotrophin releasing factor (CRF), sauvagine and urotensin I. Urocortin is derived from a larger precursor protein (pro-urocortin, also named corticotensin). Urocortin has biological actions similar to CRF such as stress-related endocrine, autonomic and behavioral responses in mammalian species. It is a potent stimulator of adrenocorticotropic hormone (ACTH) secretion by corticotroph cells from the anterior pituitary in vitro and in vivo.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
生物信息学
蛋白别名: Corticotensin; prepro-urocortin; Urocortin; urocortin, preproprotein
基因别名: Mpv17; UCN; Ucn1; UI; UROC
UniProt ID: (Human) P55089, (Rat) P55090, (Mouse) P81615
Entrez Gene ID: (Human) 7349, (Rat) 29151, (Mouse) 22226
startle response
inflammatory response
response to oxidative stress
G-protein coupled receptor signaling pathway
neuropeptide signaling pathway
female pregnancy
sensory perception of sound
associative learning
aerobic respiration
negative regulation of gene expression
response to auditory stimulus
pancreatic juice secretion
positive regulation of cell growth
positive regulation of cAMP biosynthetic process
negative regulation of histone deacetylation
neuron projection development
negative regulation of appetite
response to estradiol
positive regulation of interleukin-6 production
positive regulation of collagen biosynthetic process
positive regulation of peptidyl-serine phosphorylation
activation of protein kinase A activity
social behavior
gastric emptying
drinking behavior
negative regulation of apoptotic process
positive regulation of vascular permeability
positive regulation of translation
positive regulation of DNA replication
negative regulation of blood pressure
negative regulation of cell size
positive regulation of vasodilation
positive regulation of transcription from RNA polymerase II promoter
negative regulation of hormone secretion
response to pain
response to glucocorticoid
positive regulation of corticotropin secretion
regulation of synaptic transmission, glutamatergic
positive regulation of cardiac muscle contraction
negative regulation of gastric acid secretion
negative regulation of necrotic cell death
positive regulation of calcium ion import
negative regulation of neuron death
negative regulation of feeding behavior
positive regulation of behavioral fear response
positive regulation of protein phosphorylation
learning or memory
feeding behavior
positive regulation of gene expression
negative regulation of cell death
response to immobilization stress
response to starvation
negative regulation of catalytic activity
prepulse inhibition
