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Urokinase Antibody (MA5-49935) in IHC (P)
Immunohistochemistry analysis with a Urokinase monoclonal antibody (Product # MA5-49935) using a dilution of 1:100 and staining in paraffin-embedded human prostate cancer performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30 min at RT. Then primary antibody (1% BSA) was... View More
产品信息
MA5-49935
产品规格
种属反应
Human
宿主/亚型
Rabbit
/ IgG
Expression System
HEK293 cells
分类
Recombinant Monoclonal
类型
Antibody
克隆号
10E5
抗原
A synthesized peptide derived from human Urokinase
偶联物
形式
Liquid
浓度
3.1 mg/mL
纯化类型
Affinity chromatography
保存液
PBS, pH 7.4, with 50% glycerol
内含物
0.02% sodium azide
保存条件
-20°C or -80°C if preferred
运输条件
Wet ice
RRID
AB_3092716
靶标信息
This gene encodes a serine protease involved in degradation of the extracellular matrix and possibly tumor cell migration and proliferation. A specific polymorphism in this gene may be associated with late-onset Alzheimer's disease and also with decreased affinity for fibrin-binding. This protein converts plasminogen to plasmin by specific cleavage of an Arg-Val bond in plasminogen. Plasmin in turn cleaves this protein at a Lys-Ile bond to form a two-chain derivative in which a single disulfide bond connects the amino-terminal A-chain to the catalytically active, carboxy-terminal B-chain. This two-chain derivative is also called HMW-uPA (high molecular weight uPA). HMW-uPA can be further processed into LMW-uPA (low molecular weight uPA) by cleavage of chain A into a short chain A (A1) and an amino-terminal fragment. LMW-uPA is proteolytically active but does not bind to the uPA receptor. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: antagonist of uPA; HGNC:9052; plasminogen activator; plasminogen activator, urinary; U-plasminogen activator; UPAR; URKR; Urokinase-type plasminogen activator
基因别名: ATF; BDPLT5; PLAU; QPD; u-PA; UPA; URK
UniProt ID: (Human) P00749
Entrez Gene ID: (Human) 5328
angiogenesis
proteolysis
chemotaxis
signal transduction
spermatogenesis
embryo implantation
blood coagulation
positive regulation of cell proliferation
regulation of receptor activity
response to activity
smooth muscle cell migration
regulation of smooth muscle cell migration
positive regulation of smooth muscle cell migration
positive regulation of cell migration
regulation of cell adhesion mediated by integrin
cellular response to hepatocyte growth factor stimulus
fibrinolysis
skeletal muscle tissue regeneration
response to hyperoxia
positive regulation of ovulation
regulation of wound healing
neuron death
cellular response to lipopolysaccharide
cellular response to glucose stimulus
cellular response to hypoxia
cellular response to fluid shear stress
cellular response to staurosporine
regulation of smooth muscle cell-matrix adhesion
regulation of hepatocyte proliferation
positive regulation of reactive oxygen species metabolic process
