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Uteroglobin Antibody (PA5-79956) in IHC (P)
Immunohistochemistry analysis of Uteroglobin on paraffin-embedded mouse lung tissue. Antigen retrieval was performed using citrate buffer (pH6, epitope retrieval solution) for 20 mins. Sample was blocked using 10% goat serum, incubated with Uteroglobin polyclonal antibody (Product# PA5-79956) with a dilution of 1 µg/mL (overnight at 4°C), and followed by biotinylated goat anti-rabbit IgG (30 minutes at 37°C... View More
产品信息
PA5-79956
产品规格
种属反应
Mouse
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
E. coli-derived mouse Uteroglobin recombinant protein (Position: D22-F96).
偶联物
形式
Lyophilized
浓度
500 µg/mL
纯化类型
Antigen affinity chromatography
保存液
PBS with 4mg trehalose
内含物
0.05mg sodium azide
保存条件
-20°C
运输条件
Wet ice
RRID
AB_2747071
产品详细信息
Reconstitute with 0.2 mL of distilled water to yield a concentration of 500 µg/mL.
靶标信息
Uteroglobin, which is a member of the Secretoglobin superfamily and is also known as Clara cell phospholipid-binding protein, is a multifunctional protein that can exert anti-inflammatory and anti-tumorigenic effects by binding small hydrophobic molecules such as phospholipids and prostaglandins. The small, non-glycosylated protein named for its high levels of expression in pre-implantation embryos, where it exhibits growth stimulatory effects, is produced and secreted by the non-ciliated, non-mucous Clara cells predominant in the epithelial surfaces of pulmonary airways, as well as other non-ciliated epithelia. Members of the Secretoglobin superfamily demonstrate a high level of structural conservation and are characterized as small, secretory homo- or heterodimers. In addition to sequestering pro-inflammatory mediators and carcinogens, Uteroglobin has been implicated in the inhibition of cell migration and invasion, platelet aggregation, and T cell differentiation.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: Blastokinin; CC10; CCPBP; clara cell 17 kDa protein; clara cell phospholipid-binding protein; clara cell secretory protein; clara cells 10 kDa secretory protein; Club cell 17 kDa protein; Club cell phospholipid-binding protein; Club cells 10 kDa secretory protein; PCB-binding protein; Secretoglobin family 1A member 1; Uteroglobin
基因别名: CC10; CC16; CCSP; PCB-BP; Scgb1a1; UG; UGB; Utg
UniProt ID: (Mouse) Q06318
Entrez Gene ID: (Mouse) 22287
negative regulation of transcription from RNA polymerase II promoter
signal transduction
negative regulation of interferon-gamma production
negative regulation of interleukin-13 production
negative regulation of interleukin-4 production
negative regulation of interleukin-5 production
response to cytokine
negative regulation of T cell proliferation
regulation of mRNA stability
regulation of inflammatory response
