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产品信息
PA5-23207
产品规格
种属反应
Bovine,
Dog,
Human,
Mouse,
Non-human primate,
Rat
已发表种属
Mouse
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
A portion of amino acids 300-350 of human Van Gogh like-2 protein
偶联物
形式
Liquid
浓度
0.5 mg/mL
纯化类型
Protein G
保存液
PBS with 0.05% BSA
内含物
0.05% sodium azide
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Ambient (domestic); Wet ice (international)
RRID
AB_2540733
靶标信息
Van Gogh is an alternate name for the Drosophila strabismus protein. Van Gogh like-2 (VANGL2) is a 521 amino acidprotein in vertebrates similar to strabismus 1 of Drosophila and a component of the frizzled-disheveled tissue polarity pathway. It interacts through it's C-terminal region with the N-terminal half of DVL1, DVL2 and DVL3 and is a potent tumor suppressor. It ispredominantly involved in the control of early morphogenesis and patterning of both axial midline structures and the development of neural plate. It plays a crucial role in the regulation of planar cell polarity, particularly in the orientation of stereociliary bundles in the cochlea. VANGL2 is required for polarization and movement of myocardializing cells and seems to act via RHOA signaling to regulate this process. It is expressed in a wide range of tissues.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
生物信息学
蛋白别名: loop tail associated protein; Loop-tail protein 1; Loop-tail protein 1 homolog; Loop-tail-associated protein; MGC119403; MGC119404; Strabismus 1; Van Gogh-like protein 2; vang; vang (van gogh)-like 2; vang-like 2 (van gogh, Drosophila); Vang-like protein 2; vangl2 {ECO:0000312|RGD:1309442}
基因别名:
C530001F03Rik; KIAA1215; loop-tail; Lp; LPP1; LTAP; ska17; ska
UniProt ID: (Human) Q9ULK5, (Rat) P84889, (Mouse) Q91ZD4
Entrez Gene ID: (Human) 57216, (Bovine) 520544, (Dog) 610037, (Rat) 289229, (Mouse) 93840
establishment of planar polarity
neural tube closure
hair follicle development
heart looping
membranous septum morphogenesis
muscular septum morphogenesis
planar cell polarity pathway involved in axis elongation
Rho protein signal transduction
anterior/posterior pattern specification
heparan sulfate proteoglycan biosynthetic process
convergent extension involved in neural plate elongation
regulation of Wnt signaling pathway
glomerulus development
regulation of actin cytoskeleton organization
somatic stem cell population maintenance
nonmotile primary cilium assembly
cell migration involved in kidney development
post-anal tail morphogenesis
dopaminergic neuron axon guidance
serotonergic neuron axon guidance
wound healing
positive regulation of JUN kinase activity
apical protein localization
establishment or maintenance of epithelial cell apical/basal polarity
somatic stem cell division
establishment of body hair planar orientation
digestive tract morphogenesis
convergent extension involved in axis elongation
inner ear receptor stereocilium organization
orthogonal dichotomous subdivision of terminal units involved in lung branching morphogenesis
planar dichotomous subdivision of terminal units involved in lung branching morphogenesis
lateral sprouting involved in lung morphogenesis
kidney morphogenesis
planar cell polarity pathway involved in heart morphogenesis
cochlea morphogenesis
establishment of planar polarity involved in neural tube closure
planar cell polarity pathway involved in neural tube closure
biological_process
non-canonical Wnt signaling pathway
convergent extension involved in organogenesis
Wnt signaling pathway, planar cell polarity pathway
inner ear receptor cell development
cochlea development
regulation of establishment of planar polarity
patterning of blood vessels
outflow tract septum morphogenesis
epicardial cell to mesenchymal cell transition
multicellular organism development
cardiac vascular smooth muscle cell differentiation
establishment of epithelial cell polarity
