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产品信息
75-496
应用
建议稀释比
已发表文章
产品规格
种属反应
Mouse,
Rat
宿主/亚型
Mouse
/ IgG2b
分类
Monoclonal
类型
Antibody
克隆号
N479/107
抗原
Fusion protein amino acids 1-219 (N-terminus) of rat VAPA (accession number Q9Z270) produced recombinantly in E. Coli.
偶联物
Unconjugated
形式
Liquid
浓度
1 mg/mL
纯化类型
Protein A
保存液
TBS, pH 7.4
内含物
0.065% sodium azide
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Ambient (domestic); Dry ice (international)
产品详细信息
For maximum recovery of product, centrifuge the vial prior to removing the cap.
靶标信息
VAPA/VAPB may play a role in vesicle trafficking. Present in the plasma membrane and in intracellular vesicles. Interacts with VAMP1 and VAMP2. Subunit: Homodimer, and heterodimer with VAPA. Subcellular Location: Cell membrane; Single-pass type IV membrane protein. Intracytoplasmic membrane; Single-pass type IV membrane protein. Tissue Specificity: Ubiquitous. Isoform 1 predominates. Disease: Defects in VAPB are the cause of amyotrophic lateral sclerosis type 8 (ALS8). ALS8 is a familial form of amyotrophic lateral sclerosis, a neurodegenerative disorder affecting upper and lower motor neurons and resulting in fatal paralysis. Sensory abnormalities are absent. Death usually occurs within 2 to 5 years. The etiology of amyotrophic lateral sclerosis is likely to be multifactorial, involving both genetic and environmental factors. The disease is inherited in 5-10% of cases leading to familial forms. Defects in VAPB are a cause of proximal adult autosomal dominant spinal muscular atrophy; also called late-onset spinal muscular atrophy Finkel type. Spinal muscular atrophies are neurodegenerative disorders characterized by degeneration of lower motor neurons, leading to progressive paralysis muscular atrophy. This form is a late- adult-onset form of the disease (after age 20 years). The patients show a benign course, most of them remaining ambulatory 10 to 40 years after clinical onset.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: 33 kDa VAMP-associated protein; synaptobrevin-associated protein of 33kDa; VAMP-A; VAMP-associated protein 33b; VAMP-associated protein A; VAMP-associated protein B; VAMP-B; VAP-33; VAP-A; VAP-B; vesicle-associated membrane protein, associated protein a; vesicle-associated membrane protein, associated protein B and C; Vesicle-associated membrane protein-associated protein A; Vesicle-associated membrane protein-associated protein B
基因别名: 33kDa; AI225786; AI840687; AI848259; D2Abb2e; R75548; Vamp33b; VAP33; VAP33b; Vapa; Vapb
UniProt ID: (Rat) Q9Z270, (Mouse) Q9WV55, (Rat) Q9Z269
Entrez Gene ID: (Rat) 58857, (Mouse) 30960, (Rat) 60431, (Mouse) 56491
ER to Golgi vesicle-mediated transport
endoplasmic reticulum organization
signal transduction
cell death
neuron projection development
protein folding in endoplasmic reticulum
positive regulation of I-kappaB kinase/NF-kappaB signaling
positive regulation by host of viral release from host cell
negative regulation by host of viral genome replication
positive regulation by host of viral genome replication
protein localization to endoplasmic reticulum
COPII-coated vesicle budding
cellular calcium ion homeostasis
activation of signaling protein activity involved in unfolded protein response
biological_process
modulation by virus of host morphology or physiology
endoplasmic reticulum unfolded protein response
negative regulation by host of viral release from host cell
positive regulation of viral genome replication
negative regulation by virus of viral protein levels in host cell
response to unfolded protein
