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产品信息
VKORC1-101AP
应用
建议稀释比
已发表文章
产品规格
种属反应
Human,
Mouse,
Rat
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Synthetic peptide taken within amino acid region 10-60 on human VKORC1 protein.
偶联物
形式
Liquid
浓度
0.5-1.5 mg/mL
纯化类型
Affinity chromatography
保存液
proprietary buffer, pH 7.4-7.8, with 0.5% BSA, 30% glycerol
内含物
0.02% sodium azide
保存条件
-20°C
运输条件
Ambient (domestic); Wet ice (international)
靶标信息
Vitamin K epoxide reductase complex subunit 1 (VKORC1) is the enzyme that is responsible for reducing vitamin K 2,3-epoxide to the enzymatically activated form which is essential for blood clotting. This enzymatically activated form of vitamin K is a reduced form required for the carboxylation of glutamic acid residues in some blood-clotting proteins. Fatal bleeding can be caused by vitamin K deficiency and by the vitamin K antagonist warfarin, and it is VKORC1 that is sensitive to warfarin. In humans, mutations in this gene can be associated with deficiencies in vitamin-K-dependent clotting factors and, in humans and rats, with warfarin resistance.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: IMAGE3455200; phylloquinone epoxide reductase; vitamin K dependent clotting factors deficiency 2; Vitamin K epoxide reductase complex subunit 1; vitamin K epoxide reductase complex, subunit 1; Vitamin K1 2,3-epoxide reductase subunit 1; vitamin K1 epoxide reductase (warfarin-sensitive); Warfarin resistance
基因别名: D7Wsu86e; EDTP308; MST134; MST576; MSTP134; MSTP576; UNQ308/PRO351; VKCFD2; VKOR; VKORC1
UniProt ID: (Human) Q9BQB6, (Rat) Q6TEK4, (Mouse) Q9CRC0
Entrez Gene ID: (Human) 79001, (Rat) 309004, (Mouse) 27973
blood coagulation
drug metabolic process
peptidyl-glutamic acid carboxylation
vitamin K metabolic process
oxidation-reduction process
bone development
response to organonitrogen compound
response to organic cyclic compound
regulation of blood coagulation
response to antibiotic
positive regulation of coagulation
vitamin K biosynthetic process
