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Viperin Antibody (PA5-59457) in WB
Western blot analysis of Viperin in control (vector only transfected HEK293T lysate) and RSAD2 over-expression lysate (Co-expressed with a C-terminal myc-DDK tag (~3.1 kDa) in mammalian HEK293T cells). Samples were probed using a Viperin Polyclonal Antibody (Product # PA5-59457).
产品信息
PA5-59457
产品规格
种属反应
Human
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
偶联物
形式
Liquid
浓度
0.3 mg/mL
纯化类型
Antigen affinity chromatography
保存液
PBS, pH 7.2, with 40% glycerol
内含物
0.02% sodium azide
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Wet ice
RRID
AB_2649436
产品详细信息
Immunogen sequence: EAERFVIGDE EFERFLERHK EVSCLVPESN QKMKDSYLIL DEYMRFLNCR KGRKDPSKSI LDVGVEEAIK FSGFDEKMFL KRGGKYIWSK ADLKLDW
Highest antigen sequence identity to the following orthologs: Mouse - 93%, Rat - 90%.
靶标信息
Viperin is a 43kDa protein which is one of several hundred interferon inducible viral proteins. Elevated expression of viperin is induced by LPS and poly I:C through TLR dependent signaling pathways. Sendai virus mediated viperin expression is induced independently of TLR signaling pathways through RLRs - RIG-I and MAVs (Severa, 2006). Viperin has been shown to play an important role in interferon mediated anti-viral activity in a Hepatitis C virus model system (Helbig, 2011). Viperin is induced in lymphoid cells and dendritic cells (DCs) and highly induced in neutrophils and macrophages during acute LCMV infection in mice (Hinson, ). Viperin functions as a mediator of viral resistance and as a marker for interferon responsiveness making its detection and mechanism of action through specific antibody probes valuable for further studies.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: Cytomegalovirus-induced gene 5 protein; Radical S-adenosyl methionine domain-containing protein 2; RSAD2; S-adenosylmethionine-dependent nucleotide dehydratase RSAD2; SAND; Viperin; Virus inhibitory protein, endoplasmic reticulum-associated, interferon-inducible
基因别名: 2510004L01Rik; cig33; CIG5; RSAD2; vig1
UniProt ID: (Human) Q8WXG1
Entrez Gene ID: (Human) 91543
response to virus
positive regulation of toll-like receptor 7 signaling pathway
positive regulation of toll-like receptor 9 signaling pathway
CD4-positive, alpha-beta T cell activation
CD4-positive, alpha-beta T cell differentiation
negative regulation of viral genome replication
negative regulation of protein secretion
defense response to virus
type I interferon signaling pathway
positive regulation of T-helper 2 cell cytokine production
