Invitrogen

WAC Polyclonal Antibody

产品信息

PA5-57705

应用

建议稀释比

已发表文章

免疫组化 (IHC)

1:50-1:200

产品规格

种属反应

Human

宿主/亚型

Rabbit / IgG

分类

Polyclonal

类型

Antibody

抗原

Recombinant protein corresponding to Human WAC. Recombinant protein control fragment (Product #RP-97019).

查看免疫原

偶联物

Unconjugated Unconjugated Unconjugated

形式

Liquid

浓度

0.1 mg/mL

纯化类型

Antigen affinity chromatography

保存液

PBS, pH 7.2, with 40% glycerol

内含物

0.02% sodium azide

保存条件

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

运输条件

Wet ice

RRID

AB_2649522

产品详细信息

Immunogen sequence: RLSDGCHDRR GDSQPYQALK YSSKSHPSSG DHRHEKMRDA GDPSPPNKML RRSDSPENKY SDSTGHSKAK NVHTHRVRER DGGTSYSPQE NSH

Highest antigen sequence identity to the following orthologs: Mouse - 95%, Rat - 91%.

靶标信息

The WW domain containing adaptor with coiled-coil protein (WAC) contains a WW domain that mediates protein-protein interactions and colocalizes with RNA splicing factor SC35. Further studies have indicated that WAC is a functional partner of the RNF20/40 complex that ubiquitinates Histone H2B, and that WAC regulates H2B ubiquitination. WAC targets RNF20/40 to associate with RNA polymerase II complex for H2B ubiquitination at active transcription sites. WAC-dependent transcription is also important for cell-cycle checkpoint activation in response to genotoxic stress.

仅用于科研。不用于诊断过程。未经明确授权不得转售。