Invitrogen

WARS2 Polyclonal Antibody

图: 1 / 3

WARS2 Antibody (PA5-43808) in WB

Western blot analysis of human fetal muscle cell lysate using an anti-WARS2 polyclonal antibody (Product # PA5-43808). Lane 1) Primary Antibody; Lane 2) Primary Antibody + Blocking Peptide.

Product Image Gallery

产品信息

PA5-43808

应用

建议稀释比

已发表文章

免疫印迹 (WB)

0.2-1 µg/mL

查看2篇已发表文章 2篇已发表文章

产品规格

种属反应

Human

已发表种属

Human

宿主/亚型

Rabbit / IgG

分类

Polyclonal

类型

Antibody

抗原

Synthetic peptide directed towards the middle region of human WARS2

偶联物

Unconjugated Unconjugated Unconjugated

形式

Liquid

浓度

0.5 mg/mL

纯化类型

Affinity Chromatography

保存液

PBS with 2% sucrose

内含物

0.09% sodium azide

保存条件

-20° C, Avoid Freeze/Thaw Cycles

运输条件

Wet ice

RRID

AB_2576729

产品详细信息

Peptide sequence: TTKQKHDGTV GLLTYPVLQA ADILLYKSTH VPVGEDQVQH MELVQDLAQG

Sequence homology: Cow: 100%; Dog: 100%; Guinea Pig: 100%; Horse: 100%; Human: 100%; Mouse: 100%; Rabbit: 100%; Rat: 100%; Yeast: 93%; Zebrafish: 93%

靶标信息

Aminoacyl-tRNA synthetases catalyze the aminoacylation of tRNA by their cognate amino acid. Because of their central role in linking amino acids with nucleotide triplets contained in tRNAs, aminoacyl-tRNA synthetases are thought to be among the first proteins that appeared in evolution. Two forms of tryptophanyl-tRNA synthetase exist, a cytoplasmic form, named WARS, and a mitochondrial form, named WARS2. This gene encodes the mitochondrial tryptophanyl-tRNA synthetase. Two alternative transcripts encoding different isoforms have been described.

仅用于科研。不用于诊断过程。未经明确授权不得转售。

Product References

The Expanding Phenotypical Spectrum of WARS2-Related Disorder: Four Novel Cases with a Common Recurrent Variant.

Genes

Pauly MG,Korenke GC,Diaw SH,Grözinger A,Cazurro-Gutiérrez A,Pérez-Dueñas B,González V,Macaya A,Serrano Antón AT,Peterlin B,Božović IB,Maver A,Münchau A,Lohmann K

PA5-43808 was used in Western Blotting to investigate the mitochondrial function in patients and found increased levels of mitochondrially encoded cytochrome C Oxidase II as part of the mitochondrial respiratory chain as well as decreased mitochondrial integrity and branching.

Wed Mar 29 00:00:00 EDT 2023

Biallelic variants in WARS2 encoding mitochondrial tryptophanyl-tRNA synthase in six individuals with mitochondrial encephalopathy.

Human mutation

Wortmann SB,Timal S,Venselaar H,Wintjes LT,Kopajtich R,Feichtinger RG,Onnekink C,Mühlmeister M,Brandt U,Smeitink JA,Veltman JA,Sperl W,Lefeber D,Pruijn G,Stojanovic V,Freisinger P,V Spronsen F,Derks TG,Veenstra-Knol HE,Mayr JA,Rötig A,Tarnopolsky M,Prokisch H,Rodenburg RJ