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产品信息
H00008976-M04
应用
建议稀释比
已发表文章
产品规格
种属反应
Human
宿主/亚型
Mouse
/ IgG2b, kappa
分类
Monoclonal
类型
Antibody
克隆号
5F4
抗原
WASL (NP_003932, 97 a.a. approximately 184 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
偶联物
形式
Liquid
浓度
1 mg/mL
纯化类型
Protein A
保存液
PBS, pH 7.4
内含物
no preservative
保存条件
-20° C, Avoid Freeze/Thaw Cycles
运输条件
Wet ice
产品详细信息
Product may be used with Western Blot (Cell lysate).
Immunogen sequence: NFVYNSPRGY FHTFAGDTCQ VALNFANEEE AKKFRKAVTD LLGRRQRKSE KRRDPPNGPN LPMATVDIKN PEITTNRFYG PQVNNISH
靶标信息
The Wiskott-Aldrich syndrome (WAS) family of proteins share similar domain structure, and are involved in transduction of signals from receptors on the cell surface to the actin cytoskeleton. The presence of a number of different motifs suggests that they are regulated by a number of different stimuli, and interact with multiple proteins. Recent studies have demonstrated that these proteins, directly or indirectly, associate with the small GTPase, Cdc42, known to regulate formation of actin filaments, and the cytoskeletal organizing complex, Arp2/3. The WASL gene product is a homolog of WAS protein, however, unlike the latter, it is ubiquitously expressed and shows highest expression in neural tissues. It has been shown to bind Cdc42 directly, and induce formation of long actin microspikes.
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生物信息学
蛋白别名: Actin nucleation-promoting factor WASL; DKFZp779G0847; MGC48327; n wasp; N-WASP; Neural Wiskott-Aldrich syndrome protein; Wiskott-Aldrich syndrome-like
基因别名: N-WASP; NWASP; WASL; WASPB
UniProt ID: (Human) O00401
Entrez Gene ID: (Human) 8976
transcription, DNA-templated
regulation of transcription, DNA-templated
protein complex assembly
membrane budding
movement of cell or subcellular component
mitotic nuclear division
actin polymerization or depolymerization
response to bacterium
vesicle organization
vesicle transport along actin filament
regulation of protein localization
cellular protein complex localization
Fc-gamma receptor signaling pathway involved in phagocytosis
ephrin receptor signaling pathway
regulation of nitric-oxide synthase activity
cell division
positive regulation of filopodium assembly
spindle localization
negative regulation of membrane tubulation
positive regulation of clathrin-mediated endocytosis
negative regulation of lymphocyte migration
positive regulation of Arp2/3 complex-mediated actin nucleation
