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产品信息
MA5-22129
产品规格
种属反应
Human
宿主/亚型
Mouse
/ IgG2b, kappa
分类
Monoclonal
类型
Antibody
克隆号
1F3
抗原
WDR41 (AAH40241, 1 a.a. ~ 459 a.a) full-length recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
偶联物
形式
Liquid
浓度
0.2-1.0 mg/mL
纯化类型
Affinity chromatography
保存液
PBS, pH 7.4
内含物
no preservative
保存条件
-20° C, Avoid Freeze/Thaw Cycles
运输条件
Ambient (domestic); Wet ice (international)
RRID
AB_2577234
产品详细信息
Peptide Sequence: MLRWLIGGGR EPQGLAEKSP LQTIGEEQTQ NPYTELLVLK AHHDIVRFLV QLDDYRFASA GDDGIVVVWN AQTGEKLLEL NGHTQKITAI ITFPSLESCE EKNQLILTAS ADRTVIVWDG DTTRQVQRIS CFQSTVKCLT VLQRLDVWLS GGNDLCVWNR KLDLLCKTSH LSDTGISALV EIPKNCVVAA VGKELIIFRL VAPTEGSLEW DILEVKRLLD HQDNILSLIN VNDLSFVTGS HVGELIIWDA LDWTMQAYER NFWDPSPQLD TQQEIKLCQK SNDISIHHFT CDEENVFAAV GRGLYVYSLQ MKRVIACQKT AHDSNVLHVA RLPNRQLISC SEDGSVRIWE LREKQQLAAE PVPTGFFNMW GFGRVSKQAS QPVKKQQENA TSCSLELIGD LIGHSSSVEM FLYFEDHGLV TCSADHLIIL WKNGERESGL RSLRLFQKLE ENGDLYLAV
靶标信息
Non-catalytic component of the C9orf72-SMCR8 complex, a complex that has guanine nucleotide exchange factor (GEF) activity and regulates autophagy. The C9orf72-SMCR8 complex promotes the exchange of GDP to GTP, converting inactive GDP-bound RAB8A and RAB39B into their active GTP-bound form, thereby promoting autophagosome maturation. As part of the C9orf72-SMCR8 complex, stimulates RAB8A and RAB11A GTPase activity in vitro, however WDR42 is shown not be an essential complex component for this function. The C9orf72-SMCR8 complex also acts as a negative regulator of autophagy initiation by interacting with the ULK1/ATG1 kinase complex and inhibiting its protein kinase activity.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: WD repeat-containing protein 41
基因别名: MSTP048; WDR41
UniProt ID: (Human) Q9NV62
Entrez Gene ID: (Human) 55255
