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WDR48 Antibody (PA5-76203) in IHC (P)
Immunohistochemistry analysis of WDR48 in paraffin-embedded rat liver. Samples were incubated with WDR48 polyclonal antibody (Product # PA5-76203) using a dilution of 1:100. Perform microwave antigen retrieval with 10 mM PBS buffer pH 7.2 before commencing with IHC staining protocol.
产品信息
PA5-76203
产品规格
种属反应
Human,
Mouse,
Rat
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Recombinant fusion protein of human WDR48.
偶联物
形式
Liquid
浓度
1 mg/mL
纯化类型
Antigen affinity chromatography
保存液
PBS, pH 7.2, with 50% glycerol
内含物
0.02% sodium azide
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Wet ice
RRID
AB_2719930
产品详细信息
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
靶标信息
WD-repeats are motifs that are found in a variety of proteins and are characterized by a conserved core of 40-60 amino acids, which commonly form a tertiary propeller structure. While proteins that contain WD-repeats participate in a wide range of cellular functions, they are generally involved in regulatory mechanisms involving signal transduction, apoptosis, transcriptional regulation and cell cycle control. WD repeats serve as sites for protein-protein interaction and some seem to mediate the assembly of protein complexes. With eight WD repeats, WDR48 (WD repeat-containing protein 48), also known as USP1-associated factor 1 and p80, is a 677 amino acid protein that functions to regulate deubiquitinating complexes via activation of USP1, USP12 and USP46. WDR48 enhances deubiquitination by increasing catalytic turnover without increasing the affinity of deubiquitinating enzymes for the substrate. WDR48 is ubiquitously expressed and is mainly localized to the cytoplasm. There are five isoforms of WDR48 that are expressed as a result of alternative splicing events.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: p80; testicular tissue protein Li 224; USP1 associated factor 1; USP1-associated factor 1; WD repeat endosomal protein; WD repeat-containing protein 48
基因别名: 8430408H12Rik; KIAA1449; mKIAA1449; P80; RGD1309702; SPG60; UAF1; WDR48
UniProt ID: (Human) Q8TAF3, (Mouse) Q8BH57
Entrez Gene ID: (Human) 57599, (Rat) 363164, (Mouse) 67561
double-strand break repair via homologous recombination
cellular response to DNA damage stimulus
spermatogenesis
single fertilization
male gonad development
protein deubiquitination
multicellular organism growth
skin development
embryonic organ development
skeletal system morphogenesis
homeostasis of number of cells
positive regulation of epithelial cell proliferation
seminiferous tubule development
regulation of protein monoubiquitination
viral process
