Invitrogen

WFS1 Polyclonal Antibody

查看其他5个WFS1抗体

抗体检测数据 (1)

WFS1 Antibody in Immunohistochemistry (IHC)

WFS1 Antibody in Immunohistochemistry (IHC)

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WFS1 Antibody (PA5-56064) in IHC

Immunohistochemical staining of WFS1 in human heart muscle using a WFS1 Polyclonal Antibody (Product # PA5-56064) shows moderate cytoplasmic positivity in myocytes.

WFS1 Antibody in Immunohistochemistry (IHC)

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WFS1 Antibody in Immunohistochemistry (IHC) — Immunohistochemical staining of WFS1 in human heart muscle using a WFS1 Polyclonal Antibody (Product # PA5-56064) shows moderate cytoplasmic positivity in myocytes.

产品信息

PA5-56064

应用

建议稀释比

已发表文章

免疫组化（石蜡） (IHC (P))

1:50-1:200

-

产品规格

种属反应

Human

宿主/亚型

Rabbit / IgG

分类

Polyclonal

类型

Antibody

抗原

Recombinant protein corresponding to Human WFS1. Recombinant protein control fragment (Product #RP-90661).

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偶联物

Unconjugated Unconjugated Unconjugated

形式

Liquid

浓度

0.1 mg/mL

纯化类型

Antigen affinity chromatography

保存液

PBS, pH 7.2, with 40% glycerol

内含物

0.02% sodium azide

保存条件

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

运输条件

Wet ice

RRID

AB_2649642

产品详细信息

Immunogen sequence: KHPCHIKKFD RYKFEITVGM PFSSGADGSR SREEDDVTKD IVLRASSEFK SVLLSLRQGS LIEFSTILEG RLGSKWPVFE LKAISCLNCM AQLSPTRRHV KIEHDW

Highest antigen sequence identity to the following orthologs: Mouse - 88%, Rat - 88%.

靶标信息

WFS1 is a novel component of Wolfram syndrome, a rare form of juvenile diabetes. WFS1 plays an important role in maintaining homeostasis of the endoplasmic reticulum (ER) in the pancreas. It is normally up-regulated during insulin secretion, whereas inactivation of the protein can cause ER stress. Chronic ER stress is a major involvement in Wolfram syndrome.

仅用于科研。不用于诊断过程。未经明确授权不得转售。

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引用该产品

生物信息学

蛋白别名: Wolfram antibody; Wolfram syndrome 1 (wolframin); Wolframin

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基因别名: CTRCT41; WFRS; WFS; WFS1; WFSL

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UniProt ID: (Human) O76024

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Entrez Gene ID: (Human) 7466

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protein binding ubiquitin protein ligase binding activating transcription factor binding ATPase binding

参与通路

negative regulation of transcription from RNA polymerase II promoter kidney development renal water homeostasis ER overload response visual perception sensory perception of sound protein maturation by protein folding ER-associated ubiquitin-dependent protein catabolic process positive regulation of protein ubiquitination endoplasmic reticulum calcium ion homeostasis response to endoplasmic reticulum stress IRE1-mediated unfolded protein response glucose homeostasis negative regulation of programmed cell death negative regulation of sequence-specific DNA binding transcription factor activity negative regulation of neuron apoptotic process positive regulation of adenylate cyclase activity positive regulation of growth protein stabilization neurological system process positive regulation of protein metabolic process positive regulation of calcium ion transport calcium ion homeostasis negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway negative regulation of ATF6-mediated unfolded protein response negative regulation of type B pancreatic cell apoptotic process