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Immunogen sequence: MQRPSLPDLS RPNTTSSTGM KHSSSAPPPP PPGRRANAPP TPLPMHSSKA PAYNREKPLP PTPGQRLHPG REGPPAPP
Highest antigen sequence identity to the following orthologs: Mouse - 92%, Rat - 92%.
This gene belongs to the GPI family whose members encode multifunctional phosphoglucose isomerase proteins involved in energy pathways. The protein encoded by this gene is a dimeric enzyme that catalyzes the reversible isomerization of glucose-6-phosphate and fructose-6-phosphate. The protein functions in different capacities inside and outside the cell. In the cytoplasm, the gene product is involved in glycolysis and gluconeogenesis, while outside the cell it functions as a neurotrophic factor for spinal and sensory neurons. Defects in this gene are the cause of nonspherocytic hemolytic anemia and a severe enzyme deficiency can be associated with hydrops fetalis, immediate neonatal death and neurological impairment.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
蛋白别名: WAS/WASL interacting protein family, member 2; WAS/WASL-interacting protein family member 2; WASP-binding protein; WASP-interacting protein-related protein; WIP- and CR16-homologous protein; WIP-related protein
基因别名: PP10631; WICH; WIPF2; WIRE
UniProt ID: (Human) Q8TF74
Entrez Gene ID: (Human) 147179