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Immunogen sequence: GTLAAITFNA SGSKLASASE KGTVIRVFSV PDGQKLYEFR RGMKRYVTIS SLVFSMDSQF LCASSNTETV HIFKLEQVTN SRPEEPSTWS GYMGKMFMAA TNYLPTQVSD MMHQDRAFAT ARLNFSGQRN ICTLSTIQKL PRLLVASSSG HLYMYNLDPQ DGGECVLIKT HSLLGSGTTE ENKENDLRPS LPQSYAATVA RPSASSASTV PGYSEDGGAL RGEVIPEHEF ATGPVCLDDE NEFPPIILCR GNQKGKTKQS
WIPI1 (WD repeat domain, phosphoinositide interacting-1), also known as WIPI1, ATG18 or WIPI49, is thought to play a role in autophagy and may regulate protein trafficking in certain recycling pathways. It contains three WD repeats and has a 7-bladed propeller structure with a conserved motif that facilitates its interaction with other proteins. WIPI1 localizes to cytoplasmic vesicles, endosomes, clathrin-coated vesicles and the trans-Golgi network. It is ubiquitously expressed with highest expression in heart, testis, placenta, pancreas and skeletal muscle. WIPI1 is upregulated in a variety of tumors, suggesting a role in carcinogenesis.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
蛋白别名: Atg18 protein homolog; WD repeat domain phosphoinositide-interacting protein 1; WD40 repeat protein interacting with phosphoinositides of 49 kDa; WD40 repeat protein Interacting with phosphoInositides of 49kDa; WIPI 49 kDa; WIPI-1; WIPI-1 alpha
基因别名: 4930533H01Rik; ATG18; ATG18A; AW411817; D11Ertd498e; RGD1307754; WIPI1; WIPI49
UniProt ID: (Human) Q5MNZ9, (Mouse) Q8R3E3
Entrez Gene ID: (Human) 55062, (Rat) 303630, (Mouse) 52639